DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCP1 and dcp1b

DIOPT Version :9

Sequence 1:	NP_001163282.1	Gene:	DCP1 / 37790	FlyBaseID:	FBgn0034921	Length:	372	Species:	Drosophila melanogaster
Sequence 2:	NP_001038620.2	Gene:	dcp1b / 568176	ZFINID:	ZDB-GENE-040819-1	Length:	499	Species:	Danio rerio

Alignment Length:	514	Identity:	130/514 - (25%)
Similarity:	200/514 - (38%)	Gaps:	176/514 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SITRMNLAAIKKIDPYAKEIVDSSSHVAFYTFNSSQNEWEKTDVEGAFFIYHRNAEPFHSIFINN 69
            |...|:|:|:|::|||...|.|.:|.||.||.|::.||||||:|||..|:|.|.|.|.|...|.|
Zfish    10 SCLSMSLSALKRLDPYISSITDLASQVALYTLNNNTNEWEKTNVEGTLFVYSRLASPRHGFTILN 74

  Fly    70 RLNTTSFVEPITGSLELQSQPPFLLYRNERSRIRGFWFYNSEECDRISGLVNGLLKSKDQGTNGQ 134
            ||:..:..||||..|:.|.|.|||||||.|..|.|.|||:.|:|.||:.|:..|     .|...|
Zfish    75 RLSMDNLTEPITKDLDFQLQHPFLLYRNARLSIYGIWFYDKEDCQRIAELMKNL-----AGQEQQ 134

  Fly   135 AQRHVSAPQQPKQDSSQPASIFNMLTKAQKDYN-------------------------------A 168
            .|..::......:.:.|...|..|||||:.||:                               |
Zfish   135 LQAQIATGCLSPRSAEQGVDIMQMLTKARNDYDKGKLSEPKEIGSGGIIYGQTPHLIKPIPLKPA 199

  Fly   169 Q-----------------------VSGGQPK---------------------------------- 176
            |                       :.|.|||
Zfish   200 QDAHIQAHTQHDAEMDSKHLSVVTLFGAQPKPDLGSTQPSLSVGRMGPARSSVARSLSYDDPSPA 264

  Fly   177 ------------TPSAENVTAGNVLK-FFESAKQATAESLFHRVQPLSVDQLEKQQRAATP---- 224
                        .|:...:.:|::|: ..||.:....|:...::||   |.::|......|
Zfish   265 GGAVVSSTPMQHCPAIHKLMSGSLLQPLSESPESRLCENGAVQIQP---DPIQKLLMNPPPVAGT 326

  Fly   225 ----------GE-------------------------DLLPPAGRDNHESRLSPFQKMQQLN-IQ 253
                      ||                         :.:|.||..::.  :||.:.:|:|. :|
Zfish   327 TGMPSIQLKQGEVGMGPQIHSMAKPSGPFPAQHLFVPNKVPSAGVTSNV--VSPHELLQKLTLVQ 389

  Fly   254 LLSDLKIGKSYATAQSPTVAPSSSALMANDDAGKCLRRLLAGDKPGPALMPPTMFDAPN------ 312
            ...:|   ..:.....|.:..|||.|...:     |.::::..:. ||.:.||:..:|:
Zfish   390 QEQEL---HPHQEVLQPGLTTSSSNLSKTN-----LTQVMSPQRI-PATVAPTLLLSPSVFAQTK 445

  Fly   313 --NGNPEPQQPQQPQQPLLNSTQFVQAFTYLIQNDKEFANKLHKAYLNGCSNLLLDSSS 369
              ..:|||.:.:     .|:.:|......:||:||..|.:.:::||:   |.|..||||
Zfish   446 VTRADPEPVESR-----ALSKSQLQTTLLHLIKNDASFLDTIYEAYV---SRLTTDSSS 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCP1	NP_001163282.1	Dcp1	4..124	CDD:197362	60/118 (51%)
DCP1	NP_001163282.1	mRNA_decap_C	328..362	CDD:293346	9/33 (27%)
dcp1b	NP_001038620.2	Dcp1	14..128	CDD:197362	59/113 (52%)
dcp1b	NP_001038620.2	mRNA_decap_C	456..498	CDD:293346	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582281
Domainoid	1	1.000	129	1.000	Domainoid score	I5221
eggNOG	1	0.900	-	-		E1_KOG2868
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I4014
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1509316at2759
OrthoFinder	1	1.000	-	-		FOG0002778
OrthoInspector	1	1.000	-	-		otm25415
orthoMCL	1	0.900	-	-		OOG6_106417
Panther	1	1.100	-	-	LDO	PTHR16290
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2627
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.760