Protein Alignment PHDP and PAX5

DIOPT Version :10

• Sequence 1: NP_523834.1
• Gene: PHDP / 37788
• FlyBaseID: FBgn0025334
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_057953.1
• Gene: PAX5 / 5079
• HGNCID: 8619
• Length: 391
• Species: Homo sapiens
• Alignment Length: 200
• Identity: 44/200 - (22%)
• Similarity: 74/200 - (37%)
• Gaps: 66/200 - (33%)

  Fly    51 KLCANESAIRGSLNQESSLLFSKI-TTVSEFYPA-THNI---------GSYNTDFHLKSYGDDG- 103
            ::|.|::.  .|::..:.::.:|: ...::..|| :|:|         .|.:||....||...|
Human   122 RVCDNDTV--PSVSSINRIIRTKVQQPPNQPVPASSHSIVSTGSVTQVSSVSTDSAGSSYSISGI 184

  Fly   104 LSLT----DKSKQRR--------------------IR-----TTFTSNQLNELEKIFLETHYPDI 139
            |.:|    |.:|::|                    :|     ..||..||..|:::|...||.||
Human   185 LGITSPSADTNKRKRDEGIQESPVPNGHSLPGRDFLRKQMRGDLFTQQQLEVLDRVFERQHYSDI 249

  Fly   140 YTREEIASKLHLTEARVQVWFQNRRAKFRKQERHAIYIMKDKSSKLDGRKNPVAG--SKYLGPSL 202
            :|..|.......||...                     |...:..||..|..:|.  ...:|.|:
Human   250 FTTTEPIKPEQTTEYSA---------------------MASLAGGLDDMKANLASPTPADIGSSV 293

  Fly   203 KGPQN 207
            .|||:
Human   294 PGPQS 298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PHDP	NP_523834.1	Homeodomain	113..169	CDD:459649	16/80 (20%)
PAX5	NP_057953.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PAX	16..140	CDD:128645	3/19 (16%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	19..75
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	94..142		3/21 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..218		6/35 (17%)
		Pax2_C	279..390	CDD:463563	6/19 (32%)