DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHDP and Alx1

DIOPT Version :9

Sequence 1:	NP_523834.1	Gene:	PHDP / 37788	FlyBaseID:	FBgn0025334	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_766141.1	Gene:	Alx1 / 216285	MGIID:	104621	Length:	326	Species:	Mus musculus

Alignment Length:	183	Identity:	73/183 - (39%)
Similarity:	92/183 - (50%)	Gaps:	38/183 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NSEFYNSGANG------GGLSVANHINHYNLMIDSSYKLCANESAIRGSLNQESSLLFSKITTV- 77
            |..||.....|      |.|..|.|    ::.:|            |.|..|:||:.:. ||.|
Mouse    37 NESFYGKATAGKCVQAFGPLPRAEH----HVRLD------------RTSPCQDSSVNYG-ITKVE 84

  Fly    78 -----SEFYPATHNIGSYNTD--------FHLKSYGDDGLSLTDKSKQRRIRTTFTSNQLNELEK 129
                 :|...|..|..:....        ..|...||...|....||:||.||||||.||.||||
Mouse    85 GQPLHTELNRAMDNCNNLRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEK 149

  Fly   130 IFLETHYPDIYTREEIASKLHLTEARVQVWFQNRRAKFRKQERHAIYIMKDKS 182
            :|.:|||||:|.||::|.:..||||||||||||||||:||:||:. .|.:.||
Mouse   150 VFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYG-QIQQAKS 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHDP	NP_523834.1	Homeobox	116..168	CDD:278475	38/51 (75%)
Alx1	NP_766141.1	Homeobox	135..189	CDD:395001	38/53 (72%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		4/11 (36%)
		OAR	302..320	CDD:397759
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910