DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PHDP and Phox2a

DIOPT Version :9

Sequence 1:	NP_523834.1	Gene:	PHDP / 37788	FlyBaseID:	FBgn0025334	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_446321.2	Gene:	Phox2a / 116648	RGDID:	621323	Length:	281	Species:	Rattus norvegicus

Alignment Length:	177	Identity:	73/177 - (41%)
Similarity:	95/177 - (53%)	Gaps:	28/177 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEFSLLNKANFDKDCLYTANSEFYNS-GA--NGGGLSVANHINHYNLMIDSSYKLCANESAIRGS 62
            |::|.||  ::| .|:....:..|.. ||  ..||...:        .:..::..........||
  Rat     1 MDYSYLN--SYD-SCVAAMEASAYGDFGACSQPGGFQYS--------PLRPAFPAAGPPCPALGS 54

  Fly    63 LNQESSLLFSKITTVSEFYPATHNIGSYNTDFHLKSYGDDGLSLTDKSKQRRIRTTFTSNQLNEL 127
            .|       ..:..:.:..||.::...|       .:..:...|.:|.|||||||||||.||.||
  Rat    55 SN-------CALGALRDHQPAPYSAVPY-------KFFPEPSGLHEKRKQRRIRTTFTSAQLKEL 105

  Fly   128 EKIFLETHYPDIYTREEIASKLHLTEARVQVWFQNRRAKFRKQERHA 174
            |::|.||||||||||||:|.|:.||||||||||||||||||||||.|
  Rat   106 ERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAA 152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PHDP	NP_523834.1	Homeobox	116..168	CDD:278475	42/51 (82%)
Phox2a	NP_446321.2	Homeobox	94..147	CDD:395001	43/52 (83%)
Phox2a	NP_446321.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..219		7/8 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I6693
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1505098at2759
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	1	1.000	-	-		otm44846
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2223
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920