Protein Alignment TM4SF and tspan5

DIOPT Version :10

• Sequence 1: NP_001261159.1
• Gene: TM4SF / 37786
• FlyBaseID: FBgn0020372
• Length: 292
• Species: Drosophila melanogaster
• Sequence 2: NP_001072198.1
• Gene: tspan5 / 779644
• XenbaseID: XB-GENE-868310
• Length: 268
• Species: Xenopus tropicalis
• Alignment Length: 259
• Identity: 62/259 - (23%)
• Similarity: 106/259 - (40%)
• Gaps: 48/259 - (18%)

  Fly     4 PKKIKCFKYLVYSYVVLLALTGAAQIFLGTSLLWGHSVYYGIVQNKL-------WAPAAILLCLG 61
            |:...|.||.::.:.|:..|.|..  |||.. ||..| ..|::.|..       :.|..:.|.:|
 Frog     9 PEVSCCIKYFIFGFNVIFWLLGIT--FLGVG-LWAWS-EKGVLSNISSITDLGGFDPVWLFLVVG 69

  Fly    62 PVTFILCWMGCQATNQRKRCLLGMFAALLVACICVQFIICGWSLAMRENLPTSVEIFIDDSFVEF 126
            .|.|||.:.||....:....||..|:..|.....::......:...::.:...::.||:::...:
 Frog    70 GVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLQFFINNNIRAY 134

  Fly   127 LDKFSRTKVDNLHLWNRMQSQLQCCGVDGPLDY---------------RRLSLPWSCCSR--PEH 174
                 |..:|..:|.:..|...||||..|..|:               .|..:|:|||::  .|.
 Frog   135 -----RDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDANASRERCGVPFSCCTKDPAED 194

  Fly   175 AYESAC-------------DTHYKRGCLAVVSEQIRNRLLITAFGAAI-IAIFQSLGIFCAVHL 224
            ...:.|             :|.:.:||:....:.:::.|.|.| |..| ||:.|..||..|.:|
 Frog   195 VINTQCGYDVRQKPELDQQETIHTKGCVPQFEKWLQDNLTIVA-GVFIGIALLQIFGICLAQNL 257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM4SF	NP_001261159.1	Tetraspanin	10..224	CDD:459767	59/251 (24%)
tspan5	NP_001072198.1	Tetraspanin	15..258	CDD:459767	60/253 (24%)
		TM4SF9_like_LEL	113..233	CDD:239412	22/124 (18%)