DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ken and ZNF174

DIOPT Version :9

Sequence 1:	NP_523833.1	Gene:	ken / 37785	FlyBaseID:	FBgn0011236	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_001334797.1	Gene:	ZNF174 / 7727	HGNCID:	12963	Length:	407	Species:	Homo sapiens

Alignment Length:	329	Identity:	84/329 - (25%)
Similarity:	125/329 - (37%)	Gaps:	93/329 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   323 SHKDVMKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQS--------DNQPFTSYPHSLLEELRL 379
            |.|:::..:.|....:..|:.:|....:.::.....|.|        |.||.|  |...|.|
Human   113 SSKEIVTLVEDFHRASKKPKQWVAVCMQGQKVLLEKTGSQLGEQELPDFQPQT--PRRDLRE--- 172

  Fly   380 AKSTTSPISGFGSEKNMLAHLEDGALNGDTLTP---DRKHLL----------EAQRNRAQSPEIP 431
                :||     :|.:     :.||.  |.|:|   ::..||          ||.|.|:.:.|.|
Human   173 ----SSP-----AEPS-----QAGAY--DRLSPHHWEKSPLLQEPTPKLAGTEAPRMRSDNKENP 221

  Fly   432 MHLG-----PQFVYQWQSNQN---------AAMS---------AMPNLQ------SRLSSLSHIS 467
            ...|     |..|...:|..|         |.||         :.||.|      .|...:.:||
Human   222 QQEGAKGAKPCAVSAGRSKGNGLQNPEPRGANMSEPRLSRRQVSSPNAQKPFAHYQRHCRVEYIS 286

  Fly   468 LNL-DHPEGRSGSASGSGANLAGSNTH------ASSVREYRCEYCGKQFGMSWN--LKTHLRVHT 523
            ..| .||......:.|...:|:....|      .|:.:.|:|:.|||.|  :||  ||.|.||||
Human   287 SPLKSHPLRELKKSKGGKRSLSNRLQHLGHQPTRSAKKPYKCDDCGKSF--TWNSELKRHKRVHT 349

  Fly   524 GEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSG 588
            ||:|:.|..|...|.:::.|     .:|:.:.|      .|..|.|..|...|.....|.:|...
Human   350 GERPYTCGECGNCFGRQSTL-----KLHQRIHT------GEKPYQCGQCGKSFRQSSNLHQHHRL 403

  Fly   589 HHNN 592
            ||.:
Human   404 HHGD 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ken	NP_523833.1	BTB	27..>107	CDD:279045
		BTB	34..>107	CDD:197585
		zf-C2H2	500..522	CDD:278523	12/23 (52%)
		C2H2 Zn finger	502..522	CDD:275368	11/21 (52%)
		zf-H2C2_2	514..539	CDD:290200	14/26 (54%)
		C2H2 Zn finger	530..551	CDD:275368	4/20 (20%)
		C2H2 Zn finger	569..589	CDD:275368	5/19 (26%)
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
ZNF174	NP_001334797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..270		34/140 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4872
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950