Protein Alignment ken and BCL11B

DIOPT Version :10

• Sequence 1: NP_523833.1
• Gene: ken / 37785
• FlyBaseID: FBgn0011236
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_612808.1
• Gene: BCL11B / 64919
• HGNCID: 13222
• Length: 894
• Species: Homo sapiens
• Alignment Length: 519
• Identity: 110/519 - (21%)
• Similarity: 163/519 - (31%)
• Gaps: 161/519 - (31%)

  Fly   132 KCGGLRDRADRRKQQYTSPQNLEPDQTLKYEVDSVDESRNAADFSSAFNSNDNCESAAECERSGG 196
            |.|.|..|:|......:||   ||..:     :...|...|||.....:.:|         .|.|
Human   480 KAGSLAGRSDDGLSAASSP---EPGTS-----ELAGEGLKAADGDFRHHESD---------PSLG 527

  Fly   197 HNNKEEDEDDCTHKDNKSDKDTDEIVNLSNAPPSGTSGSNSNISTSSNHQQQQHHHHHHHNHNNN 261
            |..:||||::        :::.:|::..:.:.|..:...:|.:|
Human   528 HEPEEEDEEE--------EEEEEELLLENESRPESSFSMDSELS--------------------- 563

  Fly   262 NNNNNNNSSSSTINPVNLSLDLRTKSENSASRTLGSGSDHSGIDLAVTASE---STKRKGLFFDS 323
              .|..|....................:..:..||...::.|:.......|   ..:::|.|
Human   564 --RNRENGGGGVPGVPGAGGGAAKALADEKALVLGKVMENVGLGALPQYGELLADKQKRGAF--- 623

  Fly   324 HKDVMKPLSDGSD------------------INSSPENYVVTPHRKRRPGFHNTQSDNQPFTS-Y 369
                :|..:.|.|                  :|.....:.        ||       .:||.. :
Human   624 ----LKRAAGGGDAGDDDDAGGCGDAGAGGAVNGRGGGFA--------PG-------TEPFPGLF 669

  Fly   370 PHSLLEELRLAKSTTSPISGFGSEKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEIPMHL 434
            |.         |....|..|..|....:...:|..|....|.|...
Human   670 PR---------KPAPLPSPGLNSAAKRIKVEKDLELPPAALIPSEN------------------- 706

  Fly   435 GPQFVY-QWQSNQNAAMSAM-------------PNLQSRLSSLSHISLNLDHP---------EGR 476
                || ||.....|:...|             |...|...|..:.||....|         .||
Human   707 ----VYSQWLVGYAASRHFMKDPFLGFTDARQSPFATSSEHSSENGSLRFSTPPGDLLDGGLSGR 767

  Fly   477 SGSAS-GSGANLAGSNTHASSVREYR----CEYCGKQFGMSWNLKTHLRVHTGEKPFACRLCVAM 536
            ||:|| ||..:|.|......|.:|.|    ||||||.|....||..|.|.||||:|:.|.||...
Human   768 SGTASGGSTPHLGGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCELCNYA 832

  Fly   537 FKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLTKNLR 600
            ..|.:.|.:|:         .|:|...:..|.|..|.|.|.....|.:|:...|...|||.:::
Human   833 CAQSSKLTRHM---------KTHGQIGKEVYRCDICQMPFSVYSTLEKHMKKWHGEHLLTNDVK 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ken	NP_523833.1	BTB_POZ_BAB-like	32..117	CDD:349624
		zf-C2H2	500..522	CDD:395048	12/25 (48%)
		C2H2 Zn finger	502..522	CDD:275368	11/19 (58%)
		zf-H2C2_2	514..539	CDD:463886	12/24 (50%)
		C2H2 Zn finger	530..551	CDD:275368	6/20 (30%)
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
BCL11B	NP_612808.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..428
		zf-C2H2	428..449	CDD:395048
		C2H2 Zn finger	429..449	CDD:275370
		zf-H2C2_2	441..466	CDD:463886
		C2H2 Zn finger	457..477	CDD:275370
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..583		27/150 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..680		7/50 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	737..794		17/56 (30%)
		zf-C2H2	797..818	CDD:395048	11/20 (55%)
		C2H2 Zn finger	798..818	CDD:275368	11/19 (58%)
		zf-H2C2_2	810..835	CDD:463886	12/24 (50%)
		C2H2 Zn finger	826..846	CDD:275368	6/28 (21%)
		C2H2 Zn finger	856..874	CDD:275368	6/17 (35%)