DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ken and Zfp296

DIOPT Version :9

Sequence 1:	NP_523833.1	Gene:	ken / 37785	FlyBaseID:	FBgn0011236	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_071854.2	Gene:	Zfp296 / 63872	MGIID:	1926956	Length:	445	Species:	Mus musculus

Alignment Length:	331	Identity:	69/331 - (20%)
Similarity:	106/331 - (32%)	Gaps:	108/331 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 PVNLSLDLRTKSENSASRTLGSGSD-------HSG------IDLAVTASESTKRKGLFFDSHKDV 327
            ||: |...|:.:.:...:||.|.|:       |:|      ...:...::|:|     .:.||..
Mouse   203 PVS-SAARRSPTCDVCKKTLSSFSNLKVHMRSHTGERPYSCDQCSYACAQSSK-----LNRHKKT 261

  Fly   328 MKPLSDGSDINSSPENYVVTPHRKRRPGFHNTQSDNQPFTSYPHSLLEELRLAKSTTSPISGFGS 392
            .:.|:.||. ::|..:..|:|.....|.         .:.:.|.|.|....:.|:..:..:|
Mouse   262 HRQLAPGSP-STSASSRGVSPAAPPEPA---------AYAAAPASTLPSQTVEKAGAAATAG--- 313

  Fly   393 EKNMLAHLEDGALNGDTLTPDRKHLLEAQRNRAQSPEIP---MHLGPQFVYQWQSNQNAAMSAMP 454
                                            .|.|..|   ...||.|| .|.:......:...
Mouse   314 --------------------------------VQEPGAPGSGAQGGPGFV-GWGAPAKVERTDPV 345

  Fly   455 NLQSRLSSLSHISLNLDHPEGRSGSASGSGANLAGSNTHASSVREYRCEYCGKQFGMSWNLKTHL 519
            .::......||                |.|.               :||:|||.|..|.||..|.
Mouse   346 KIEKTAPRKSH----------------GPGG---------------KCEFCGKSFTNSSNLTVHR 379

  Fly   520 RVHTGEKPFACRLCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVR 584
            |.||||:|:.|..|.....|.:.|.:|         ..|:|..|.....|..|.:.|.....|.:
Mouse   380 RSHTGERPYTCDQCPYACAQSSKLNRH---------RRTHGLGTGKTVKCPHCLVPFGLQATLDK 435

  Fly   585 HLSGHH 590
            ||...|
Mouse   436 HLRQKH 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ken	NP_523833.1	BTB	27..>107	CDD:279045
		BTB	34..>107	CDD:197585
		zf-C2H2	500..522	CDD:278523	11/21 (52%)
		C2H2 Zn finger	502..522	CDD:275368	11/19 (58%)
		zf-H2C2_2	514..539	CDD:290200	11/24 (46%)
		C2H2 Zn finger	530..551	CDD:275368	5/20 (25%)
		C2H2 Zn finger	569..589	CDD:275368	6/19 (32%)
Zfp296	NP_071854.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..88
		C2H2 Zn finger	214..234	CDD:275370	4/19 (21%)
		zf-H2C2_2	226..251	CDD:290200	2/24 (8%)
		C2H2 Zn finger	242..262	CDD:275370	4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..359		25/164 (15%)
		COG5048	361..>410	CDD:227381	21/57 (37%)
		zf-C2H2	361..382	CDD:278523	11/20 (55%)
		C2H2 Zn finger	362..382	CDD:275368	11/19 (58%)
		zf-H2C2_2	374..399	CDD:290200	11/24 (46%)
		C2H2 Zn finger	390..410	CDD:275368	5/28 (18%)
		C2H2 Zn finger	420..438	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45993
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100