DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ken and znf296

DIOPT Version :9

Sequence 1:NP_523833.1 Gene:ken / 37785 FlyBaseID:FBgn0011236 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_001037784.1 Gene:znf296 / 553232 ZFINID:ZDB-GENE-050419-201 Length:636 Species:Danio rerio


Alignment Length:448 Identity:95/448 - (21%)
Similarity:146/448 - (32%) Gaps:134/448 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   240 STSSNHQQQQHHHHHHHNHNNNNNNNNNNSSSSTINPVNLSLDLRTKSENSASRTL-----GSGS 299
            |::.|..|.....|..:.:..::.....:..::.::|.:|...|.|..:.|:.|:.     ...|
Zfish   142 SSAWNLLQHAQITHSLNIYQEDDTPTQTSKPAAMMDPRHLGAALATAFQPSSLRSARPHKPPPSS 206

  Fly   300 DHSGIDLAVTASESTKRKGLFFDSHKDVMKPL--SDGSDINS-SPENYVVTPHRKRRPGFH---- 357
            .|...||          :||.|......:..:  |.|..:.| ||.....:|.....|..|    
Zfish   207 THVPRDL----------QGLNFSMCLQRLAEVSCSSGGVVPSPSPSPPAASPFPHSTPSIHTAFS 261

  Fly   358 ------------------NTQSDNQPFTSYPHSLLEELRLAKS------------------TTSP 386
                              .|.:.::|:    |..|.:|..::|                  |:.|
Zfish   262 CEMCGQGFQSLRSLSAHRRTHACDRPY----HCGLCQLTFSQSGELARHMRSHRRSAAGQETSDP 322

  Fly   387 ISGFGSEKNMLAHLEDGALNGDTLTPDRKH--LLEAQRNRAQSPEIPMHLGPQ-----FVYQWQS 444
            ......|...|:...|..::|.       |  .|||.::...:..|.|.|..:     .:..:|.
Zfish   323 SPASADEDRKLSGPGDNDISGG-------HGGSLEAGKHPGGASLILMPLQTRAADRNLLRYYQR 380

  Fly   445 NQNAAMSAMPNLQSRLSSLSHISLNLDHPEGRSGSASGSGAN--LAGSNTHASSVREYR------ 501
            .....:...|...|...|.|..||       .||...|||.:  .:|:.|.....||.|      
Zfish   381 EVEEEVQGEPQQPSPYGSPSEGSL-------ESGDTGGSGESGIASGNCTPKRPEREDRPQGDWE 438

  Fly   502 ---------------------------------CEYCGKQFGMSWNLKTHLRVHTGEKPFACRLC 533
                                             ||:|||.|..|.||..|.|.||||:|:.|.||
Zfish   439 QEVEAVEIVQDWQRENERRQVTNGMGKKKKEEACEFCGKCFRNSSNLTVHRRSHTGERPYRCGLC 503

  Fly   534 VAMFKQKAHLLKHLCSVHRNVITTTNGA-DTENRYSCCFCSMCFESVQELVRHLSGHH 590
            .....|.:.|.:|:         .|:|| .|...:.|..||:.|.....|.:||...|
Zfish   504 SYACAQSSKLTRHM---------KTHGARGTRAPFQCQLCSVPFTVYATLEKHLKKVH 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kenNP_523833.1 BTB 27..>107 CDD:279045
BTB 34..>107 CDD:197585
zf-C2H2 500..522 CDD:278523 12/60 (20%)
C2H2 Zn finger 502..522 CDD:275368 11/19 (58%)
zf-H2C2_2 514..539 CDD:290200 12/24 (50%)
C2H2 Zn finger 530..551 CDD:275368 6/20 (30%)
C2H2 Zn finger 569..589 CDD:275368 7/19 (37%)
znf296NP_001037784.1 C2H2 Zn finger 262..282 CDD:275368 0/19 (0%)
zf-C2H2 288..310 CDD:278523 4/25 (16%)
C2H2 Zn finger 290..310 CDD:275368 3/19 (16%)
C2H2 Zn finger 472..492 CDD:275368 11/19 (58%)
zf-C2H2 472..492 CDD:278523 11/19 (58%)
zf-H2C2_2 484..509 CDD:290200 12/24 (50%)
C2H2 Zn finger 500..520 CDD:275368 6/28 (21%)
C2H2 Zn finger 531..549 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45993
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.100

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