DRSC/TRiP Functional Genomics Resources

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Protein Alignment ken and BCL11A

DIOPT Version :9

Sequence 1:NP_523833.1 Gene:ken / 37785 FlyBaseID:FBgn0011236 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_075044.2 Gene:BCL11A / 53335 HGNCID:13221 Length:835 Species:Homo sapiens


Alignment Length:524 Identity:115/524 - (21%)
Similarity:187/524 - (35%) Gaps:154/524 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 QTLKYEVDSVDESR----------NAADFSSAFNSNDNCESAAECERSGGHNNKEEDEDDCTHKD 211
            :|.|::.:.|...|          |..|.:        |..|::.:|   |....      .||.
Human   384 KTFKFQSNLVVHRRSHTGEKPYKCNLCDHA--------CTQASKLKR---HMKTH------MHKS 431

  Fly   212 NKSDKDTDEIVNLSNAPPSGTS---GSNSNISTS---------------SNHQQQQHHHHHHHNH 258
            :.....:|:.::.:::|..|||   ||.|:...|               .|..:::.........
Human   432 SPMTVKSDDGLSTASSPEPGTSDLVGSASSALKSVVAKFKSENDPNLIPENGDEEEEEDDEEEEE 496

  Fly   259 NNNNNNNNNNSSSSTINPVNLSLDLRTKSENSA-SRTLGSGSDHSGIDLAVTASESTKRKGLFFD 322
            ...........|........|||:.....|||: ...:|.|.:...:                  
Human   497 EEEEEEEELTESERVDYGFGLSLEAARHHENSSRGAVVGVGDESRAL------------------ 543

  Fly   323 SHKDVMKPLSDGSDINSSPENYVVTPHR----KRRPGFHNTQSDNQPFTSYPHSLLEELRLAKST 383
              .|||:.:     :.||.:::....|:    |.:.| |..:::....|....|:..|       
Human   544 --PDVMQGM-----VLSSMQHFSEAFHQVLGEKHKRG-HLAEAEGHRDTCDEDSVAGE------- 593

  Fly   384 TSPISGFGSEKNMLAHLEDGALNGDTLTP--------DRKHLLEAQRNRAQSP-----------E 429
                    |::     ::||.:||...:|        .:|.||.:.  .:.||           :
Human   594 --------SDR-----IDDGTVNGRGCSPGESASGGLSKKLLLGSP--SSLSPFSKRIKLEKEFD 643

  Fly   430 IPMHLGP--QFVY-QWQSNQNAA-------MSAMPNLQSRLSSLS-----HISLNLDHPEGR-SG 478
            :|....|  :.|| ||.:...|:       :|...:.||..:|.|     :.||....|.|. .|
Human   644 LPPAAMPNTENVYSQWLAGYAASRQLKDPFLSFGDSRQSPFASSSEHSSENGSLRFSTPPGELDG 708

  Fly   479 SASG-SGANLAGSNTHAS-------SVREYR----CEYCGKQFGMSWNLKTHLRVHTGEKPFACR 531
            ..|| ||....||..|.|       |.:|.|    ||||||.|....||..|.|.||||:|:.|.
Human   709 GISGRSGTGSGGSTPHISGPGPGRPSSKEGRRSDTCEYCGKVFKNCSNLTVHRRSHTGERPYKCE 773

  Fly   532 LCVAMFKQKAHLLKHLCSVHRNVITTTNGADTENRYSCCFCSMCFESVQELVRHLSGHHNNLLLT 596
            ||.....|.:.|.:|:         .|:|...::.|.|..|.|.|.....|.:|:...|::.:|.
Human   774 LCNYACAQSSKLTRHM---------KTHGQVGKDVYKCEICKMPFSVYSTLEKHMKKWHSDRVLN 829

  Fly   597 KNLR 600
            .:::
Human   830 NDIK 833

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kenNP_523833.1 BTB 27..>107 CDD:279045
BTB 34..>107 CDD:197585
zf-C2H2 500..522 CDD:278523 12/25 (48%)
C2H2 Zn finger 502..522 CDD:275368 11/19 (58%)
zf-H2C2_2 514..539 CDD:290200 12/24 (50%)
C2H2 Zn finger 530..551 CDD:275368 6/20 (30%)
C2H2 Zn finger 569..589 CDD:275368 6/19 (32%)
BCL11ANP_075044.2 Required for nuclear body formation and for SUMO1 recruitment. /evidence=ECO:0000250 1..210
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..41
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 323..376
zf-C2H2 378..399 CDD:395048 4/14 (29%)
C2H2 Zn finger 379..399 CDD:275368 4/14 (29%)
zf-H2C2_2 391..416 CDD:404364 5/32 (16%)
C2H2 Zn finger 407..427 CDD:275368 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..458 9/45 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..512 2/40 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 572..619 11/67 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 678..740 19/61 (31%)
zf-C2H2 743..764 CDD:395048 11/20 (55%)
C2H2 Zn finger 744..764 CDD:275368 11/19 (58%)
zf-H2C2_2 756..781 CDD:404364 12/24 (50%)
C2H2 Zn finger 772..792 CDD:275368 6/28 (21%)
C2H2 Zn finger 802..820 CDD:275368 6/17 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45993
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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