DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mtpbeta and B0303.3

DIOPT Version :9

Sequence 1:	NP_477378.1	Gene:	Mtpbeta / 37784	FlyBaseID:	FBgn0025352	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_498915.1	Gene:	B0303.3 / 176216	WormBaseID:	WBGene00015125	Length:	448	Species:	Caenorhabditis elegans

Alignment Length:	440	Identity:	270/440 - (61%)
Similarity:	334/440 - (75%)	Gaps:	7/440 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RALSAAVANPQPKQKNSQNIVLVDGVRTPFLTSGTTYSKLMPHELARHSLLSLLQKNRLDKELID 89
            ||.||..      :||..||||||.|||||:.|||.:..||..:|.:.::.:|::|.:|..|.:|
Worm    13 RAASAVA------KKNMPNIVLVDAVRTPFVVSGTVFKDLMAVDLQKEAIKALVEKTKLPYEQLD 71

  Fly    90 YIVYGSVIQEVKTSNIAREAALAAGFSNKTPAHTVTMACISSNAAITTGMGLIATNTYDVIVAGG 154
            :|:.|:||||.|||||||||||.||..:|.||||||:||||||.|:|||||::||...:.|:|||
Worm    72 HIICGTVIQECKTSNIAREAALLAGVPDKIPAHTVTLACISSNVAMTTGMGMLATGNANAIIAGG 136

  Fly   155 VEFMSDVPIRHSRKMRSLLLKANKAKTLGQRLALLSTFRPDFLAPELPAVAEFSSGETMGHSADR 219
            ||.:||||||::|..|..:|..||||.:..:|.:......:.|:||||||||||:|||||||.||
Worm   137 VELLSDVPIRYNRNARKAMLGMNKAKDVPSKLKIGGQIVKNLLSPELPAVAEFSTGETMGHSGDR 201

  Fly   220 LASAFNVSRSEQDEYALRSHTLAKEAQEKGYFTDLVPFKVSG-VDQIVDKDNGIRVSSPESLAKL 283
            ||:||||||.||||:|:||||||.||.:.|.|||:||..:.| ..:.:.:|||||||:.|.|:.|
Worm   202 LAAAFNVSRREQDEFAIRSHTLASEAAKNGKFTDVVPVFLDGKKPKTIKEDNGIRVSTLEKLSSL 266

  Fly   284 RPAFVKPYGTVTAANASFLTDGASACIIMTEEKAKQLGLKPKAYLRDFLFVSQDPVNQLLLGPAY 348
            :||||||:|||||||||:|||||||.:|||||.|...|.||||||||:|:|:|||.:||||.|||
Worm   267 KPAFVKPHGTVTAANASYLTDGASAALIMTEEYALANGYKPKAYLRDYLYVAQDPKDQLLLSPAY 331

  Fly   349 GIPKLLKKAGLTLKDIDSWEIHEAFAGQIVANLKALDSDWFCKTYLGLNEKVGTPDLSKWNNWGG 413
            .|||||.||||||||:|.:|||||||||::|||.|:|||:|||..:..:.|.|...:.|.|.|||
Worm   332 VIPKLLDKAGLTLKDVDVFEIHEAFAGQVLANLNAMDSDYFCKEQMKRSGKFGRVPMDKLNLWGG 396

  Fly   414 SLSIGHPFAATGVRLCMHTANRLVREDGKLGVVAACAAGGQGVAMLIERY 463
            ||||||||.||||||..|:|:||..|.|:..|:|||||||.||.||||.|
Worm   397 SLSIGHPFGATGVRLATHSAHRLKEEKGQYAVIAACAAGGHGVGMLIEAY 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mtpbeta	NP_477378.1	fadI	44..462	CDD:181597	261/418 (62%)
Mtpbeta	NP_477378.1	thiolase	45..462	CDD:238383	260/417 (62%)
B0303.3	NP_498915.1	thiolase	27..445	CDD:238383	260/417 (62%)
B0303.3	NP_498915.1	AcCoA-C-Actrans	29..444	CDD:273881	257/414 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159102
Domainoid	1	1.000	324	1.000	Domainoid score	I646
eggNOG	1	0.900	-	-		E1_COG0183
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H153
Inparanoid	1	1.050	522	1.000	Inparanoid score	I681
Isobase	1	0.950	-	0	Normalized mean entropy	S1047
OMA	1	1.010	-	-		QHG63432
OrthoDB	1	1.010	-	-		D1129049at2759
OrthoFinder	1	1.000	-	-		FOG0006445
OrthoInspector	1	1.000	-	-		oto18755
orthoMCL	1	0.900	-	-		OOG6_104606
Panther	1	1.100	-	-	LDO	PTHR18919
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2909
SonicParanoid	1	1.000	-	-		X4701
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790