DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TBPH and HNRNPDL

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_112740.1 Gene:HNRNPDL / 9987 HGNCID:5037 Length:420 Species:Homo sapiens


Alignment Length:348 Identity:101/348 - (29%)
Similarity:157/348 - (45%) Gaps:41/348 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 KYRNLDTKAVRGVRSNEGRLFPPSVES----GWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIE 101
            |..::...|.....:...|..||:..|    ...||:....|.:.:|..:..|.::.        
Human    91 KSSSIQRSAAAAAATRTARQHPPADSSVTMEDMNEYSNIEEFAEGSKINASKNQQDD-------- 147

  Fly   102 TRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL- 165
                 ..:.:.||.|.|:::.|.||...:|||:...||.|..:|:|:|||||.|....:..:|| 
Human   148 -----GKMFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLE 207

  Fly   166 TNRHLIDGRWCEVKVPNSKGM-GHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIP----- 224
            ...|.:||:..:.|  .:|.: |.:.|.|||||..:.|.:.:.::|||..|||:.::.:|     
Human   208 LKEHKLDGKLIDPK--RAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKT 270

  Fly   225 RPFRAFSFVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHS 288
            ...|.|.|:|:.|.: |.:.|....|.|......:..|.|| |..|.||.|......|.:.|...
Human   271 NERRGFCFITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPK-EVYRQQQQQQKGGRGAAAGGRGG 334

  Fly   289 Y----HPQGNHMNPGRNGHH-RG-NNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGG-NSGGGY 346
            .    ..||.:.|.|.|.:: :| .|.::|:||:     .|:: |..||...|.|||. ..|.||
Human   335 TRGRGRGQGQNWNQGFNNYYDQGYGNYNSAYGGD-----QNYS-GYGGYDYTGYNYGNYGYGQGY 393

  Fly   347 HNNGGNHSSGGNTNRQDGGSQYN 369
            .:..|..|:.|..:|..|..|.|
Human   394 ADYSGQQSTYGKASRGGGNHQNN 416

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833 8/40 (20%)
RRM1_TDP43 108..181 CDD:409760 27/73 (37%)
RRM2_TDP43 192..261 CDD:409761 22/74 (30%)
HNRNPDLNP_112740.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..83
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 96..120 5/23 (22%)
RRM1_hnRPDL 149..224 CDD:410152 27/76 (36%)
RRM2_hnRPDL 234..308 CDD:409998 22/73 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..348 8/34 (24%)
Necessary for interaction with TNPO1. /evidence=ECO:0000269|PubMed:9524220 342..420 28/81 (35%)
Necessary for its nuclear import and export 396..420 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..420 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.