Protein Alignment TBPH and RBM39

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 185
• Identity: 45/185 - (24%)
• Similarity: 73/185 - (39%)
• Gaps: 36/185 - (19%)

  Fly    80 KENKRKSDDNL--ENSTAKT---KRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIK 139
            |...|:..|||  |...|:|   .::..|:|..|              |.|:|.|.|:|...::.
Human   135 KSPVREPIDNLTPEERDARTVFCMQLAARIRPRD--------------LEEFFSTVGKVRDVRMI 185

  Fly   140 KDTKSGQSKGFGFVRFGSYDA--------QMRVLTNRHLIDGRWCE----VKVPNSKGMGHQVPC 192
            .|..|.:|||..:|.|....:        ..|||....::.....|    ..:.|:...|...|.
Human   186 SDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPM 250

  Fly   193 KVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRP-----FRAFSFVTFLDPDVAQ 242
            :::||....:|..|.||..|..||.:..:.:...     .:.:.|:||.|.:.|:
Human   251 RLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAK 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	18/84 (21%)
		RRM2_TDP43	192..261	CDD:409761	14/56 (25%)
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146		4/10 (40%)
		SF-CC1	46..518	CDD:273721	45/185 (24%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		5/15 (33%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		5/15 (33%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530