DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TBPH and HRP1

DIOPT Version :9

Sequence 1:NP_001163280.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_014518.1 Gene:HRP1 / 853997 SGDID:S000005483 Length:534 Species:Saccharomyces cerevisiae


Alignment Length:528 Identity:124/528 - (23%)
Similarity:189/528 - (35%) Gaps:151/528 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 EEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVESGWGEYAYFCVFP----- 79
            :|..|...:...|...|..||.:..|        :....:...||.:|           |     
Yeast    97 QESATSANANANASSAGPSGLPWEQL--------QQTMSQFQQPSSQS-----------PPQQQV 142

  Fly    80 ---KENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKD 141
               ||.:.|:|  |...:.|            :.:.||.|.|||::|||||..||.|...:|.||
Yeast   143 TQTKEERSKAD--LSKESCK------------MFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKD 193

  Fly   142 TKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVK--VPNSKGMGHQVPCKVFVGRCTEDIN 204
            ..:|:|:||||:.|....:...|:..:|::||:..:.|  :|..:   .....|:|||....|:.
Yeast   194 PATGRSRGFGFLSFEKPSSVDEVVKTQHILDGKVIDPKRAIPRDE---QDKTGKIFVGGIGPDVR 255

  Fly   205 SDDLREYFSKFGEVTDVFI-----PRPFRAFSFVTFLDPDVAQSLCGEDHI-IKGVSVHVSNAAP 263
            ..:..|:||::|.:.|..:     ....|.|.|||:...|....:|....| .|...:.:..|.|
Yeast   256 PKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRAEP 320

  Fly   264 KAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGT 328
                 |:.|.:|.|                   |.|.||   |||.                   
Yeast   321 -----RHMQQKSSN-------------------NGGNNG---GNNM------------------- 339

  Fly   329 AGYGMGGNNYGGNSG--GGYHNNGGNHSSGGNT---NRQDGGSQYNSRQSNFHGMNQPHNGNVGG 388
                   |..|||.|  |.::....|...||..   |.|.....|...|..:..|.:        
Yeast   340 -------NRRGGNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQQMQK-------- 389

  Fly   389 SNGW---------MNRGHLDMPNL----QALGIN--------SQGS--------SSSNQGQNMSN 424
            ..|.         |.:..:.||..    .|:.:|        :|||        :.||..|.:.|
Yeast   390 QTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQTIGN 454

  Fly   425 QSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQ----QGGNFLSWMAQNGGHNNANNFGGR 485
            .|..:..|.|:|........:|::...|.....|:|:    :......:..::||::..|..|||
Yeast   455 TSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYGYNRDRGDRDRNDRDRDYNHRSGGNHRRNGRGGR 519

  Fly   486 KGPNNPNN 493
            .|.|..||
Yeast   520 GGYNRRNN 527

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_001163280.1 RRM1_TDP43 108..184 CDD:240767 30/77 (39%)
RRM2_TDP43 192..261 CDD:240768 19/74 (26%)
HRP1NP_014518.1 PABP-1234 <144..463 CDD:130689 96/396 (24%)
RRM1_Hrp1p 161..236 CDD:409991 29/74 (39%)
RRM2_Hrp1p 244..321 CDD:409767 21/81 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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