Protein Alignment TBPH and HRP1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_014518.1
• Gene: HRP1 / 853997
• SGDID: S000005483
• Length: 534
• Species: Saccharomyces cerevisiae
• Alignment Length: 528
• Identity: 124/528 - (23%)
• Similarity: 189/528 - (35%)
• Gaps: 151/528 - (28%)

  Fly    20 EEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVESGWGEYAYFCVFP----- 79
            :|..|...:...|...|..||.:..|        :....:...||.:|           |
Yeast    97 QESATSANANANASSAGPSGLPWEQL--------QQTMSQFQQPSSQS-----------PPQQQV 142

  Fly    80 ---KENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKD 141
               ||.:.|:|  |...:.|            :.:.||.|.|||::|||||..||.|...:|.||
Yeast   143 TQTKEERSKAD--LSKESCK------------MFIGGLNWDTTEDNLREYFGKYGTVTDLKIMKD 193

  Fly   142 TKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVK--VPNSKGMGHQVPCKVFVGRCTEDIN 204
            ..:|:|:||||:.|....:...|:..:|::||:..:.|  :|..:   .....|:|||....|:.
Yeast   194 PATGRSRGFGFLSFEKPSSVDEVVKTQHILDGKVIDPKRAIPRDE---QDKTGKIFVGGIGPDVR 255

  Fly   205 SDDLREYFSKFGEVTDVFI-----PRPFRAFSFVTFLDPDVAQSLCGEDHI-IKGVSVHVSNAAP 263
            ..:..|:||::|.:.|..:     ....|.|.|||:...|....:|....| .|...:.:..|.|
Yeast   256 PKEFEEFFSQWGTIIDAQLMLDKDTGQSRGFGFVTYDSADAVDRVCQNKFIDFKDRKIEIKRAEP 320

  Fly   264 KAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGT 328
                 |:.|.:|.|                   |.|.||   |||.
Yeast   321 -----RHMQQKSSN-------------------NGGNNG---GNNM------------------- 339

  Fly   329 AGYGMGGNNYGGNSG--GGYHNNGGNHSSGGNT---NRQDGGSQYNSRQSNFHGMNQPHNGNVGG 388
                   |..|||.|  |.::....|...||..   |.|.....|...|..:..|.:
Yeast   340 -------NRRGGNFGNQGDFNQMYQNPMMGGYNPMMNPQAMTDYYQKMQEYYQQMQK-------- 389

  Fly   389 SNGW---------MNRGHLDMPNL----QALGIN--------SQGS--------SSSNQGQNMSN 424
            ..|.         |.:..:.||..    .|:.:|        :|||        :.||..|.:.|
Yeast   390 QTGMDYTQMYQQQMQQMAMMMPGFAMPPNAMTLNQPQQDSNATQGSPAPSDSDNNKSNDVQTIGN 454

  Fly   425 QSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQ----QGGNFLSWMAQNGGHNNANNFGGR 485
            .|..:..|.|:|........:|::...|.....|:|:    :......:..::||::..|..|||
Yeast   455 TSNTDSGSPPLNLPNGPKGPSQYNDDHNSGYGYNRDRGDRDRNDRDRDYNHRSGGNHRRNGRGGR 519

  Fly   486 KGPNNPNN 493
            .|.|..||
Yeast   520 GGYNRRNN 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	10/57 (18%)
		RRM1_TDP43	108..181	CDD:409760	29/74 (39%)
		RRM2_TDP43	192..261	CDD:409761	19/74 (26%)
HRP1	NP_014518.1	PABP-1234	<144..463	CDD:130689	96/396 (24%)
		RRM1_Hrp1p	161..236	CDD:409991	29/74 (39%)
		RRM2_Hrp1p	244..321	CDD:409767	21/81 (26%)