Protein Alignment TBPH and NGR1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_009771.3
• Gene: NGR1 / 852513
• SGDID: S000000416
• Length: 672
• Species: Saccharomyces cerevisiae
• Alignment Length: 641
• Identity: 123/641 - (19%)
• Similarity: 184/641 - (28%)
• Gaps: 256/641 - (39%)

  Fly    28 STLQAQFPGSCGLKYR-NLDTKAVRGVRSNE-GRLFPPSVES------------GWGEYAYFCVF 78
            ||.|....|.|.:::. ..|.|....:.:.. ...:.|:..|            .|.
Yeast   121 STTQLHHAGYCFVEFETQKDAKFALSLNATPLPNFYSPTTNSQTNPTFKRTFRLNWA-------- 177

  Fly    79 PKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFET-YGEVLMAQIKKDT 142
                   |...|::|...|...       .|.|..|....||..|...|:| :..|...::..|.
Yeast   178 -------SGATLQSSIPSTPEF-------SLFVGDLSPTATEADLLSLFQTRFKSVKTVRVMTDP 228

  Fly   143 KSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVK---------------------------- 179
            .:|.|:.|||||||..|.:.|.|..   :.|:|.:.:
Yeast   229 LTGSSRCFGFVRFGDEDERRRALIE---MSGKWFQGRALRVAYATPRNNMMLQLQEQQQQQQQLQ 290

  Fly   180 -----------------------VPNSKGM-----GHQVP------------------------- 191
                                   :.|:..|     .|..|
Yeast   291 QQHQQLDQEDNNGPLLIKTANNLIQNNSNMLPLNALHNAPPMHLNEGGISNMRVNDSLPSNTYNT 355

  Fly   192 ----CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTF---LDPDVA-QSLCG-- 246
                ..||||..........||..|..||.:.:|.||.. :...||.|   :|.:.: |.|.|
Yeast   356 DPTNTTVFVGGLVPKTTEFQLRSLFKPFGPILNVRIPNG-KNCGFVKFEKRIDAEASIQGLQGFI 419

  Fly   247 -------------------EDHIIKGVSVHVSN---AAPKAE---QNRNQQVQSYNYNSANSFGM 286
                               .:..|.|.|.::|:   .||.|.   .|..|.::.|..:....| :
Yeast   420 VGGSPIRLSWGRPSSSNAKTNSTIMGASQYMSSNGLRAPSAASSVDNSKQILEQYAEDKRRLF-L 483

  Fly   287 HSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGG 351
            |....|               .|.....|..::....||          |.|..|:...:.|..|
Yeast   484 HQQQQQ---------------QQQQQQDGNFSMEQMAHN----------NYYNYNNYDYHRNKNG 523

  Fly   352 NHSSGGNTNR-------QDGG---SQYNSRQSNFHGM---------NQPHNGNVGGSNGWMNRGH 397
            :||...|..|       :||.   .||:|...:.|..         |.|..||....:
Yeast   524 SHSDLVNLQRSNVPYMQEDGALYPHQYSSPSYSLHPTGNQFSNATNNLPQFGNAMSIS------- 581

  Fly   398 LDMPNLQALGINSQGSSS--SNQGQNMSNQSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQD 460
            :.:||    |.:::.:||  :|...||...|.:|:| :.:||
Yeast   582 MQLPN----GNSNKTASSMNTNPNTNMIMNSNMNMN-MNVNP----------------------- 618

  Fly   461 QQGGNFLSWMAQNGGHNNANNFGGRK---GPNN--PNNNPAANGIKTDNSEPQNGN 511
                      ...|..|.||.:...:   .|.|  ||:|.:.:.|.  |..|...|
Yeast   619 ----------VPYGMGNGANMYDVSRMMTPPLNIAPNSNNSKSSIM--NKHPNRNN 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	10/63 (16%)
		RRM1_TDP43	108..181	CDD:409760	24/124 (19%)
		RRM2_TDP43	192..261	CDD:409761	23/96 (24%)
NGR1	NP_009771.3	RRM1_NGR1_NAM8_like	35..180	CDD:410023	11/73 (15%)
		RRM2_NGR1_NAM8_like	191..270	CDD:410025	24/88 (27%)
		RRM3_NGR1_NAM8_like	359..430	CDD:409782	19/71 (27%)