Protein Alignment TBPH and NPL3

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_010720.3
• Gene: NPL3 / 852042
• SGDID: S000002840
• Length: 414
• Species: Saccharomyces cerevisiae
• Alignment Length: 333
• Identity: 75/333 - (22%)
• Similarity: 112/333 - (33%)
• Gaps: 82/333 - (24%)

  Fly    99 RIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMR 163
            |.|..|..|.|.|...|....|..|.|.|..:|.:...:|        ..||.||.|...::..:
Yeast   117 RQEGELSNTRLFVRPFPLDVQESELNEIFGPFGPMKEVKI--------LNGFAFVEFEEAESAAK 173

  Fly   164 VLTNRHLIDGRWCEVKVPNSKGMGHQ--------VPCK---VFVGRCTEDINSDDLREYF----- 212
            .:...|             .|...:|        :|.|   :.:....|..:..||::..
Yeast   174 AIEEVH-------------GKSFANQPLEVVYSKLPAKRYRITMKNLPEGCSWQDLKDLARENSL 225

  Fly   213 -SKFGEVTDVFIPRPFRAFSFVTFLDPDV-AQSLCGEDHI-IKGVSVHV---SNAAPKAEQNRNQ 271
             :.|..|.    .|.|.....:.|...:: .::|...::| .:|..:.|   .|..|....||.
Yeast   226 ETTFSSVN----TRDFDGTGALEFPSEEILVEALERLNNIEFRGSVITVERDDNPPPIRRSNRG- 285

  Fly   272 QVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRG--NNQHNAHGGENAIVPNNHNIGTAGYGMG 334
                 .:.....|       :|......|.|..||  .......||...        |..||..|
Yeast   286 -----GFRGRGGF-------RGGFRGGFRGGFSRGGFGGPRGGFGGPRG--------GYGGYSRG 330

  Fly   335 GNNYGGNSGGGYHNNGGNHSS--GGNTNRQDGGSQ--YNSRQSNFHGMNQPHNGNVGGSNGWMN- 394
            |  |||.|.|||..:.|.:.|  ||..:.:.|.|:  |...::::    .|..|:.|||.|..:
Yeast   331 G--YGGYSRGGYGGSRGGYDSPRGGYDSPRGGYSRGGYGGPRNDY----GPPRGSYGGSRGGYDG 389

  Fly   395 -RGHLDMP 401
             ||....|
Yeast   390 PRGDYGPP 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	15/72 (21%)
		RRM2_TDP43	192..261	CDD:409761	13/82 (16%)
NPL3	NP_010720.3	PHA03247	<11..87	CDD:223021
		RBD_RRM1_NPL3	126..192	CDD:409777	17/86 (20%)
		RRM2_SRSF1_4_like	200..271	CDD:409776	11/74 (15%)