Protein Alignment TBPH and TIF35

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_010717.1
• Gene: TIF35 / 852039
• SGDID: S000002837
• Length: 274
• Species: Saccharomyces cerevisiae
• Alignment Length: 306
• Identity: 60/306 - (19%)
• Similarity: 109/306 - (35%)
• Gaps: 89/306 - (29%)

  Fly    14 PIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVR-------------------SNEGR 59
            |.|:....||:..:.|.:.:    .|:||:  .|:.|:.|:                   |.:|.
Yeast     6 PEEIIENADGSRSIITYKIE----DGVKYK--ITQKVKEVKVLEKVHKSVAERKNWHKYGSEKGS 64

  Fly    60 LFPPS-VESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKR--IETRLRCTDLIVLGLPWKTTEE 121
            ...|| |.:..||.....: .:..|:..::.::...|...:  ::.||...|.:.:..|:||...
Yeast    65 PAGPSAVTARLGEEVELRL-SRNWKQAEEERIQKEKASLTKTGLQCRLCGNDHMTMNCPFKTILS 128

  Fly   122 SLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGM 186
            .|....:........:...:.|:||..|.|.:. |.|                     ||.|:..
Yeast   129 ELSALEDPATNEGGVEAASEEKAGQVGGAGSIP-GQY---------------------VPPSRRA 171

  Fly   187 GHQVP--------------CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRP----------- 226
            |.:.|              |.:.:.:..|:.:.:.|||      |:...|.|.|
Yeast   172 GARDPSSDAYRDSRERDDMCTLKIMQVNENADENSLRE------ELLFPFAPIPRVSVVRNKETG 230

  Fly   227 -FRAFSFVTFLDPDVAQS----LCGEDHIIKGVSVHVSNAAPKAEQ 267
             .|..:||||...:||:.    |.|..::  .:.:.|..:.||.::
Yeast   231 KSRGLAFVTFSSEEVAEQALRFLDGRGYM--NLILRVEWSKPKVKE 274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	18/83 (22%)
		RRM1_TDP43	108..181	CDD:409760	12/72 (17%)
		RRM2_TDP43	192..261	CDD:409761	19/84 (23%)
TIF35	NP_010717.1	eIF3g	6..127	CDD:463545	26/127 (20%)
		RRM_eIF3G_like	192..268	CDD:409842	18/83 (22%)