DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and RBM4B

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_113680.1 Gene:RBM4B / 83759 HGNCID:28842 Length:359 Species:Homo sapiens


Alignment Length:378 Identity:79/378 - (20%)
Similarity:124/378 - (32%) Gaps:116/378 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDG 173
            |.:..||.:.||:.:|..||.||:||...|        .|.:|||......|....:.|.|....
Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDI--------IKNYGFVHIEDKTAAEDAIRNLHHYKL 60

  Fly   174 RWCEVKVPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDP 238
            ....:.|..||... :...|:.||..:....:.:||..|.::|.|.:..|.:.: ||        
Human    61 HGVNINVEASKNKS-KASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDY-AF-------- 115

  Fly   239 DVAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGH 303
                             ||:..|....|..|               |:.:...||..|:      
Human   116 -----------------VHMERAEDAVEAIR---------------GLDNTEFQGKRMH------ 142

  Fly   304 HRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSG----GNTNR-QD 363
                           :..:...:.||. ||      |:..|.|......|.|.    ..|.| .|
Human   143 ---------------VQLSTSRLRTAP-GM------GDQSGCYRCGKEGHWSKECPVDRTGRVAD 185

  Fly   364 GGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNR-GHLD------MPNLQALGINSQGSSSSNQGQN 421
            ...|||.:   :..:..|:....|.|..:.:. |.||      :.:.:|:...:..|:.:...|.
Human   186 FTEQYNEQ---YGAVRTPYTMGYGESMYYNDAYGALDYYKRYRVRSYEAVAAAAAASAYNYAEQT 247

  Fly   422 MSNQSML-------NLNSLPINP----------------ALVAAALNQWSLVG 451
            ||:...:       :|||..::|                |:.|||....|..|
Human   248 MSHLPQVQSTTVTSHLNSTSVDPYDRHLLPNSGAAATSAAMAAAAATTSSYYG 300

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 20/71 (28%)
RRM2_TDP43 192..261 CDD:409761 13/68 (19%)
RBM4BNP_113680.1 RRM1_RBM4 2..68 CDD:410018 20/71 (28%)
RRM2_RBM4 78..144 CDD:410019 20/127 (16%)
PTZ00368 <145..>181 CDD:173561 9/42 (21%)
ZnF_C2HC 161..176 CDD:197667 4/14 (29%)
Interaction with TNPO3. /evidence=ECO:0000250 196..359 21/105 (20%)
Blue background indicates that the domain is not in the aligned region.

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