Protein Alignment TBPH and Hnrnpa0

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_084148.1
• Gene: Hnrnpa0 / 77134
• MGIID: 1924384
• Length: 305
• Species: Mus musculus
• Alignment Length: 311
• Identity: 84/311 - (27%)
• Similarity: 128/311 - (41%)
• Gaps: 53/311 - (17%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSY-DAQMRVLTNRHLID 172
            |.:.||..:|:|..||.:||.:|.:....:..:.::.:|:.||||.:.:. :|...:..:.|.:|
Mouse     9 LFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVD 73

  Fly   173 GRWCEVK-----VPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFG--EVTDVFIPRPF--- 227
            |...|:|     ..:::...|....|:|||....|:...||.|:||:||  |..::...:..
Mouse    74 GNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGAVEKAEIIADKQSGKK 138

  Fly   228 RAFSFVTFLDPDVA-QSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHP 291
            |.|.||.|...|.| ::...:.|.|:|..|.|..|.||.:                      .|.
Mouse   139 RGFGFVYFQSHDAADKAAVVKFHPIQGHRVEVKKAVPKED----------------------IHA 181

  Fly   292 QGNHMNPGRNGHHRGNNQHNAHGG----ENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGN 352
            .|......|.|...|..:....||    :|.:..     |..|.|.|.|:|||.  |||...||.
Mouse   182 GGGGARAARGGRGGGRGRGGGGGGGGRDQNGLAK-----GGGGGGGGYNSYGGY--GGYGAYGGG 239

  Fly   353 HSSGGNTNRQDGGS------QYNSRQSNFHGMNQPHNGNVGGSNGWMNRGH 397
            ...||:....|.|:      .|:..||::..|..  .|..||...|..|.:
Mouse   240 GGGGGSYGGSDYGNGFGGFGSYSQHQSSYGPMKS--GGGGGGGGSWGGRSN 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	21/77 (27%)
		RRM2_TDP43	192..261	CDD:409761	25/74 (34%)
Hnrnpa0	NP_084148.1	RRM1_hnRNPA0	5..83	CDD:409764	21/73 (29%)
		RRM_SF	99..178	CDD:473069	28/78 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	178..211		7/54 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	265..305		8/26 (31%)