Protein Alignment TBPH and Rbm31y

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_083246.1
• Gene: Rbm31y / 74484
• MGIID: 1921734
• Length: 565
• Species: Mus musculus
• Alignment Length: 500
• Identity: 127/500 - (25%)
• Similarity: 191/500 - (38%)
• Gaps: 94/500 - (18%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL-TNRHLID 172
            :.:.||..:.:::.|.||...:||::...||.|..:|.|:|||||.|.......:|| ...|.:|
Mouse    35 MFIGGLSQEMSKQVLLEYLSKFGEIIDFIIKTDPNTGLSRGFGFVLFKDSATVEKVLQVKDHKVD 99

  Fly   173 GRWCEVKVPNSKGMGHQVP-CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIP-----RPFRAFS 231
            |:..|.|  .:|.:..|.| .|:|||.....::.:.:|.||..||::..:.:|     |..|||.
Mouse   100 GKKIEFK--RAKALESQFPNKKIFVGGLNPRLSEEKIRAYFGTFGQIEAIELPLCSDTRERRAFG 162

  Fly   232 FVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPK-------------AEQNRNQQVQSYNY-NSA 281
            |:.::|.: |.:.|....|.|......|..|.||             |:....:.|.:... |:.
Mouse   163 FIKYMDENSVRKVLENRYHFIGSSRCEVKMAYPKENPARQLSKRKAIAKDRTRKSVPAVELENNW 227

  Fly   282 NSFGMHSYHPQGNH--MNPGRNGHHRGNNQHNA-------------------HGGENAIVPNN-- 323
            ...|..|:|...|.  ....::.|..|:....|                   |...|..|.|:
Mouse   228 RGGGSPSFHIMANSEAQEANQDAHRAGSYTSRANSDVTLTNACGFRDSPNAFHVNSNVFVTNSTT 292

  Fly   324 ------------HNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQD--------GGSQY 368
                        :.:|.:.|.:..|   .|:........|..|:...|::..        |.|||
Mouse   293 FIASSNALRSSTNTVGVSHYTLDAN---PNTFLASQYTLGTISNTLRTSQYTLGTYPNALGVSQY 354

  Fly   369 N-SRQSNFHGMNQ-PHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSM-LNL 430
            . :...|..|:|| |...:....  |.|:..|...: .|.||....|.:|..|..:|..|: .|.
Mouse   355 ALAAYPNTFGINQYPLEADQNAF--WTNQYPLGTYS-DAFGIGQYASGTSPNGFGVSQYSLGTNA 416

  Fly   431 NSLPINP-ALVAAALNQWS----LVGN-QLQNQNQDQQGGN---FLSWMAQNGGHNNANNFGGRK 486
            ::...|. ||||...|.|:    |..| .:...:|...|.|   |.|.....|.  ..|||
Mouse   417 DTFRTNCFALVANPYNIWTNHYVLATNPNVFRTSQYVLGENPNAFESSQYSVGA--TQNNF---- 475

  Fly   487 GPNNPNNNPAANGIKTDNSEPQNGNTGWSNQSSGSQNAAEKSNFL 531
            |||  .:|..||| ....:..:.|:||..|.|....|.....|.|
Mouse   476 GPN--QHNFGANG-NFCGTVGRGGSTGGLNFSQVYGNFLNVCNTL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	25/72 (35%)
		RRM2_TDP43	192..261	CDD:409761	21/74 (28%)
Rbm31y	NP_083246.1	RRM_SF	34..109	CDD:473069	25/75 (33%)
		RRM_SF	119..193	CDD:473069	21/73 (29%)