DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and TIA1

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_071505.2 Gene:TIA1 / 7072 HGNCID:11802 Length:386 Species:Homo sapiens


Alignment Length:338 Identity:77/338 - (22%)
Similarity:133/338 - (39%) Gaps:80/338 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 NEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTE 120
            |..::....|:..|      ...|...|:   |...::...|:|.:....   :.|..|..:.|.
Human    67 NGRKIMGKEVKVNW------ATTPSSQKK---DTSSSTVVSTQRSQDHFH---VFVGDLSPEITT 119

  Fly   121 ESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVR-FGSYDAQMRV-------LTNRHLIDGRWCE 177
            |.::..|..:|.:..|::.||..:|:|||:|||. |..:||:..:       |..|. |...|..
Human   120 EDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQ-IRTNWAT 183

  Fly   178 VKVP--------NSKGMGHQ--------VPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRP 226
            .|.|        |:|.:.:.        ..|.|:.|..|..:....:|:.||.||::.::.: .|
Human   184 RKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRV-FP 247

  Fly   227 FRAFSFVTFLDPDVAQ----SLCG---EDHIIK----GVSVHVSNAAPKAEQNRNQQVQSYN--- 277
            .:.:|||.|...:.|.    |:.|   |.|::|    ..::.:.|  |..:||:....|.|.   
Human   248 DKGYSFVRFNSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMIN--PVQQQNQIGYPQPYGQWG 310

  Fly   278 --YNSANSFGMHSYHPQGNHMNP----GRNGHHRGNNQHNA--------------HGGENAIVPN 322
              |.:|...|  .|.|.|..:..    |:..:.:|.||..:              .|...:::||
Human   311 QWYGNAQQIG--QYMPNGWQVPAYGMYGQAWNQQGFNQTQSSAPWMGPNYGVQPPQGQNGSMLPN 373

  Fly   323 NHNIGTAGYGMGG 335
            .    .:||.:.|
Human   374 Q----PSGYRVAG 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833 3/21 (14%)
RRM1_TDP43 108..181 CDD:409760 24/80 (30%)
RRM2_TDP43 192..261 CDD:409761 20/79 (25%)
TIA1NP_071505.2 RRM1_TIA1 8..81 CDD:410027 3/19 (16%)
RRM2_TIA1 104..181 CDD:410030 22/80 (28%)
RRM3_TIAR 214..286 CDD:241064 20/72 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 354..386 6/33 (18%)

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