Protein Alignment TBPH and RBM4

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_002887.2
• Gene: RBM4 / 5936
• HGNCID: 9901
• Length: 364
• Species: Homo sapiens
• Alignment Length: 196
• Identity: 47/196 - (23%)
• Similarity: 77/196 - (39%)
• Gaps: 30/196 - (15%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDG 173
            |.:..||.:.||:.:|..||.||:||...|        .|.:|||......|....:.|.|....
Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDI--------IKNYGFVHIEDKTAAEDAIRNLHHYKL 60

  Fly   174 RWCEVKVPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDP 238
            ....:.|..||... :...|:.||..:....:.:||..|.::|.|.:..|.:.: ||..:...:
Human    61 HGVNINVEASKNKS-KTSTKLHVGNISPTCTNKELRAKFEEYGPVIECDIVKDY-AFVHMERAE- 122

  Fly   239 DVAQSLCGEDHI-IKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNG 302
            |..:::.|.|:. .:|..:||             |:.:....:|...|     .|......|:.|
Human   123 DAVEAIRGLDNTEFQGKRMHV-------------QLSTSRLRTAPGMG-----DQSGCYRCGKEG 169

  Fly   303 H 303
            |
Human   170 H 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	20/71 (28%)
		RRM2_TDP43	192..261	CDD:409761	17/69 (25%)
RBM4	NP_002887.2	RRM1_RBM4	2..68	CDD:410018	20/71 (28%)
		RRM2_RBM4	78..144	CDD:410019	17/80 (21%)
		PTZ00368	<145..>181	CDD:173561	6/31 (19%)
		ZnF_C2HC	161..176	CDD:197667	3/10 (30%)
		Interaction with TNPO3. /evidence=ECO:0000269|PubMed:12628928	196..364