Protein Alignment TBPH and dazap1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_021335308.1
• Gene: dazap1 / 561459
• ZFINID: ZDB-GENE-070212-1
• Length: 469
• Species: Danio rerio
• Alignment Length: 485
• Identity: 121/485 - (24%)
• Similarity: 178/485 - (36%)
• Gaps: 121/485 - (24%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL-TNRHLID 172
            |.|.||.|.||:|:||.||..||||:...|.||..:.||:|||||:|...:....|| |..|.:|
Zfish    25 LFVGGLDWSTTQETLRNYFSQYGEVVDCVIMKDKSTNQSRGFGFVKFKDPNCVRTVLDTKPHNLD 89

  Fly   173 GRWCEVKVPNSKGM------------GHQVPC----KVFVGRCTEDINSDDLREYFSKFGEVTDV 221
            ||..:.|....:||            |.:...    |:|||....:....:||:||::||.||:|
Zfish    90 GRNIDPKPCTPRGMQPEKTRTKDGWKGSKSDSNKSKKIFVGGIPHNCGEAELRDYFNRFGVVTEV 154

  Fly   222 FI------PRPFRAFSFVTF-LDPDVAQSLCGEDHIIKGVSVHVSNAAPK-------AEQNRNQQ 272
            .:      .|| |.|.|:|| .:..|.|::....|.|.|..|.|..|.|:       .:...||.
Zfish   155 VMIYDAEKQRP-RGFGFITFEAEQSVDQAVNMHFHDIMGKKVEVKKAEPRDSKAPAPGQLGANQW 218

  Fly   273 VQSYNYNSANSFG-------MHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAG 330
            ......::||.:.       ..||.|||..::.|:                          ..||
Zfish   219 GPRAIISAANGWAAQPAPTWQQSYGPQGVWVSTGQ--------------------------PLAG 257

  Fly   331 YG---MGGNNYGGNS-------------GGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNF--HG 377
            ||   ..|......:             .||:....|....|.:|..|.|.|....:...|  .|
Zfish   258 YGPPLPAGRGAPAQAPSPFNAFLVAAPPTGGFGAPQGYPQQGFSTQPQFGYSFGTPQGDQFVAQG 322

  Fly   378 MNQPHNGNVGGSNGW---------MNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSL 433
            |..|......|..|:         :::.....|:............|:.:|:....:....|.:.
Zfish   323 MPPPPATPGAGPLGFAPATTPSQDLSKAAPAQPDFSYSQYEYLLRCSTEEGKPFMVELQEGLGNY 387

  Fly   434 PINPALVAAALNQWSLVGNQLQNQNQDQQG-----GNFLSWMAQNGGHNNANNFGGRKGPNNPNN 493
            |.:|:.........:.|        |::||     |..||..    ||:.|:       |:.|..
Zfish   388 PQDPSAYGPTRPSHTYV--------QEEQGYSAGYGQDLSAF----GHSFAD-------PSQPTA 433

  Fly   494 NPAANGIKTDNSEPQNGNTGWSNQSSGSQN 523
            :.||     ..|.|.:|....::.....||
Zfish   434 SYAA-----APSAPSSGAPAAASSFGRGQN 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	35/72 (49%)
		RRM2_TDP43	192..261	CDD:409761	27/79 (34%)
dazap1	XP_021335308.1	RRM1_DAZAP1	24..105	CDD:409988	37/79 (47%)
		RRM2_DAZAP1	127..202	CDD:409765	27/75 (36%)
		PRK10263	<220..>430	CDD:236669	44/254 (17%)