Protein Alignment TBPH and Hnrnpdl

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_057899.2
• Gene: Hnrnpdl / 50926
• MGIID: 1355299
• Length: 420
• Species: Mus musculus
• Alignment Length: 276
• Identity: 90/276 - (32%)
• Similarity: 136/276 - (49%)
• Gaps: 24/276 - (8%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL-TNRHLID 172
            :.:.||.|.|:::.|.||...:|||:...||.|..:|:|:|||||.|....:..:|| ...|.:|
Mouse   150 MFIGGLSWDTSKKDLTEYLSRFGEVVDCTIKTDPVTGRSRGFGFVLFKDAASVDKVLELKEHKLD 214

  Fly   173 GRWCEVKVPNSKGM-GHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIP-----RPFRAFS 231
            |:..:.|  .:|.: |.:.|.|||||..:.|.:.:.::|||..|||:.::.:|     ...|.|.
Mouse   215 GKLIDPK--RAKALKGKEPPKKVFVGGLSPDTSEEQIKEYFGAFGEIENIELPMDTKTNERRGFC 277

  Fly   232 FVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSY----HP 291
            |:|:.|.: |.:.|....|.|......:..|.|| |..|.||.|......|.:.|....    ..
Mouse   278 FITYTDEEPVKKLLESRYHQIGSGKCEIKVAQPK-EVYRQQQQQQKGGRGAAAGGRGGARGRGRG 341

  Fly   292 QGNHMNPGRNGHH-RG-NNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGG-NSGGGYHNNGGNH 353
            ||.:.|.|.|.:: :| .|.::|:||:     .|:: |..||...|.|||. ..|.||.:..|..
Mouse   342 QGQNWNQGFNNYYDQGYGNYNSAYGGD-----QNYS-GYGGYDYTGYNYGNYGYGQGYADYSGQQ 400

  Fly   354 SSGGNTNRQDGGSQYN 369
            |:.|..:|..|..|.|
Mouse   401 STYGKASRGGGNHQNN 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	27/72 (38%)
		RRM2_TDP43	192..261	CDD:409761	22/74 (30%)
Hnrnpdl	NP_057899.2	RRM1_hnRPDL	149..224	CDD:410152	27/75 (36%)
		RRM2_hnRPDL	234..308	CDD:409998	22/73 (30%)