Protein Alignment TBPH and tia1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_012814227.2
• Gene: tia1 / 394890
• XenbaseID: XB-GENE-1002876
• Length: 389
• Species: Xenopus tropicalis
• Alignment Length: 384
• Identity: 88/384 - (22%)
• Similarity: 137/384 - (35%)
• Gaps: 106/384 - (27%)

  Fly    56 NEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTE 120
            |..::....|:..|.        ...:.:|.|.| .:|...|.|.:....   :.|..|..:.|.
 Frog    67 NGRKIMGKEVKVNWA--------TTPSSQKKDAN-SSSVVSTLRSQDHFH---VFVGDLSPEITT 119

  Fly   121 ESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVR-FGSYDAQMRV-------LTNRHLIDGRWCE 177
            :.::..|..:|.:..|::.||..:|:|||:|||. |..:||:..:       |..|. |...|..
 Frog   120 DDIKAAFAPFGRISDARVVKDMTTGKSKGYGFVSFFNKWDAENAIAQMGGQWLGGRQ-IRTNWAT 183

  Fly   178 VKVP--------NSKGMGHQ--------VPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRP 226
            .|.|        |:|.:.::        ..|.|:.|..|..:....:|:.||.||::.:|.: .|
 Frog   184 RKPPAPKSTYESNTKQLTYEEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEVRV-FP 247

  Fly   227 FRAFSFVTFLDPDVAQ----SLCG---EDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSF 284
            .:.:|||.|...:.|.    |:.|   |.|::|   .:.....|.. .|..|||     :.|:..
 Frog   248 DKGYSFVRFSSHESAAHAIVSVNGTTIEGHVVK---CYWGKETPDM-LNPVQQV-----SEASQI 303

  Fly   285 GMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGG-NSGGGYHN 348
               |:.|.                                      ||..|..||| ...|.|..
 Frog   304 ---SFPPP--------------------------------------YGQWGQWYGGAQQIGQYVP 327

  Fly   349 NGGN---HSSGGNTNRQDGGSQYNSRQSNFHGMN---QPHNGNVG----GSNGWMNRGH 397
            ||..   :...|....|.|.||..|..:.:.|.|   ||..|..|    ...|:...|:
 Frog   328 NGWQMPAYGVYGQAWSQQGYSQTPSSAATWVGPNYGVQPQPGQNGTLITNQTGYRMAGY 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	3/21 (14%)
		RRM1_TDP43	108..181	CDD:409760	23/80 (29%)
		RRM2_TDP43	192..261	CDD:409761	21/75 (28%)
tia1	XP_012814227.2	RRM1_TIA1	8..81	CDD:410027	2/13 (15%)
		RRM2_TIA1	104..181	CDD:410030	21/80 (26%)
		RRM3_TIAR	214..286	CDD:241064	21/75 (28%)