DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TBPH and msi2b

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_957403.1 Gene:msi2b / 394084 ZFINID:ZDB-GENE-040426-1268 Length:408 Species:Danio rerio


Alignment Length:452 Identity:102/452 - (22%)
Similarity:158/452 - (34%) Gaps:100/452 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTN-RHLID 172
            :.:.||.|:|:.:|||:||..:||:....:.:|..:.:|:|||||.|....:..:||.. .|.:|
Zfish    23 MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADAASVDKVLAQPHHELD 87

  Fly   173 GRWCEVKVPNSKGMGHQVPC---KVFVGRCTEDINSDDLREYFSKFGEVTDVFI-----PRPFRA 229
            .:..:.||...:....::..   |:|||..:.:...:|:::||.:||:|.|..:     ....|.
Zfish    88 SKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRG 152

  Fly   230 FSFVTFLDPDVAQSLCG-EDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQG 293
            |.||||.:.||.:.:|. ..|.|....|....|.||...                          
Zfish   153 FGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVM-------------------------- 191

  Fly   294 NHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGM-GGNNYGGNSGGGYHNNGGNHSSGG 357
              ..||..|..||             :|...:....|.|| ...|.....|.||.....::|   
Zfish   192 --FPPGTRGRARG-------------LPYTMDAFMLGMGMLSYPNIVATYGRGYTGFAPSYS--- 238

  Fly   358 NTNRQDGGSQYNSRQSNFHGMNQPHNGNV----------GGSNGWMNR-GHLDMPNLQALGINSQ 411
                           ..|.|......|.|          |...|...| |:...|.....|....
Zfish   239 ---------------YQFPGFPATAYGPVAAAAAVAAARGSGRGARGRGGYAAYPQSTGPGFPDY 288

  Fly   412 GSSSSNQGQNMSNQSMLNLNSLPINPALVAAALNQWSLVGNQLQN-QNQDQQGGNFLSWMAQNGG 475
            |..||...|.....|..:..||....|.:..:.:..|...:.||: .:.||.         ::.|
Zfish   289 GFYSSPSDQRGPPFSFADYGSLGPQAAQLLQSEHATSACNSPLQHLASPDQY---------KSPG 344

  Fly   476 HN--NANNFGGRKGPN------NPNNNPAANGIKTDNSEPQNGNTGWSNQSSGSQNAAEKSN 529
            .|  ....|.|...|.      .|.:..:..|.....:.||.| :|:.:..:|...|...:|
Zfish   345 TNPPRPGAFPGASSPGPVADLYGPTSQDSGVGNYISAASPQPG-SGFGHSIAGPLIATAFTN 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 24/72 (33%)
RRM2_TDP43 192..261 CDD:409761 23/77 (30%)
msi2bNP_957403.1 RRM1_MSI2 17..109 CDD:410153 25/85 (29%)
RRM2_MSI 111..184 CDD:240769 23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.