Protein Alignment TBPH and tardbpa

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_073794270.1
• Gene: tardbpa / 386630
• ZFINID: ZDB-GENE-031030-1
• Length: 401
• Species: Danio rerio
• Alignment Length: 537
• Identity: 200/537 - (37%)
• Similarity: 264/537 - (49%)
• Gaps: 167/537 - (31%)

  Fly     3 FVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVES 67
            :::|:|:|.:||:|:|:|||||:||||:.|||||:|||:||:..::.:||||..||.|..|  |:
Zfish     5 YIRVAEDENEEPMEIPSEEDGTVLLSTVAAQFPGACGLRYRSPVSQCMRGVRLVEGVLHAP--EA 67

  Fly    68 GWGEYAYFCVFPKENKRKSDDNLENSTAKTKR-IETRLRCTDLIVLGLPWKTTEESLREYFETYG 131
            .||...|...:||:||||.|:....|..|.|| |:   :.:|||||||||||||:.|::||.|:|
Zfish    68 DWGNLVYVVNYPKDNKRKMDEMDAASAVKIKRGIQ---KTSDLIVLGLPWKTTEQDLKDYFGTFG 129

  Fly   132 EVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSK----GMGHQVPC 192
            ||:|.|:|:|.|||.|||||||||..|:.|::|::.||:||||||:.|:||||    ..|...|.
Zfish   130 EVIMVQVKRDAKSGNSKGFGFVRFTDYETQIKVMSQRHMIDGRWCDCKLPNSKYFLEQAGPDEPM 194

  Fly   193 ---KVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGV 254
               ||||||||||:.:|:||::|.::|||||||||:|||||:||||.|..|||||||||.||||.
Zfish   195 RSRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAQSLCGEDLIIKGT 259

  Fly   255 SVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAI 319
            |||:|||.||
Zfish   260 SVHISNAEPK------------------------------------------------------- 269

  Fly   320 VPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNG 384
                                       ||                    ||||
Zfish   270 ---------------------------HN--------------------NSRQ------------ 275

  Fly   385 NVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAA----LN 445
                   .|:||...       |...||..||.     |..|.:|..:|.:|||::|||    .:
Zfish   276 -------MMDRGRFG-------GYGGQGFGSSR-----SPNSNVNFGALNLNPAMMAAAQAALQS 321

  Fly   446 QWSLVGNQLQNQNQDQQGGNFLSWMAQNGGHNNANNFGGRKGPNNPN-------------NNPAA 497
            .|.::|.....|||....|...|  .|:|..:...|:..  ..||.|             |:.||
Zfish   322 SWGMMGMLANQQNQTPASGTNPS--GQSGSRDQTQNYSA--SSNNYNAGSSAALGWGAGTNSAAA 382

  Fly   498 NGIKTDNSEPQNGNTGW 514
            .|..:.........:.|
Zfish   383 GGFNSSFGSSMETKSSW 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	38/74 (51%)
		RRM1_TDP43	108..181	CDD:409760	48/72 (67%)
		RRM2_TDP43	192..261	CDD:409761	50/71 (70%)
tardbpa	XP_073794270.1	None