DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TBPH and hnrnpa1b

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_956398.3 Gene:hnrnpa1b / 378453 ZFINID:ZDB-GENE-030912-14 Length:403 Species:Danio rerio


Alignment Length:466 Identity:133/466 - (28%)
Similarity:180/466 - (38%) Gaps:135/466 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNR-HLID 172
            |.:.||.::||::|||.:||.:|.:....:.||..:.:|:|||||.:.|.|.....:..| |.:|
Zfish    16 LFIGGLSFETTDDSLRAHFEQWGTLTDCVVMKDPNTKRSRGFGFVTYSSVDEVNASMDARPHKVD 80

  Fly   173 GRWCEVK-----VPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFG--EVTDVFIPRPF--- 227
            ||..|.|     ..:||...|....|:|||...:|...:.||:||.:||  ||.::.:....   
Zfish    81 GRLVEPKRAVSREDSSKPFAHTTVKKIFVGGIKDDTEENHLRDYFDQFGKIEVVEIMVDHKTGNK 145

  Fly   228 RAFSFVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPKAEQ----------------NRNQQVQS 275
            |.|:||||.|.| |.:.:..:.|.:.|.:..|..|..|.|.                |.|:...:
Zfish   146 RGFAFVTFDDHDSVDRIVIQKYHTVNGHNCEVRKALSKQEMANTGRGGGGGGGGDRGNFNRYGNN 210

  Fly   276 YNYNSANSFGMHSYHPQGNHMNPGRNGHH----RGNN------QHNAHGGENAIVPNNHNIGTAG 330
            ..||  |.||       |......|:|:.    ||||      ....:||......||:..|..|
Zfish   211 GGYN--NDFG-------GGGGGGNRDGYFGRGGRGNNFGGGGGGGGGYGGGGDCYNNNNGFGGGG 266

  Fly   331 YGMGGNN-------------YGGNSGG--GYHNNGGNHSSGGNTNRQDGG-SQYNSRQSNFHGMN 379
            ||.||.|             |||..||  ||.|.||.: .|||:....|| :.||:...||.|  
Zfish   267 YGGGGGNGGGSPGNYGGNRGYGGGGGGGHGYGNQGGGY-GGGNSGGGGGGYNNYNNGNGNFGG-- 328

  Fly   380 QPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAAL 444
                ||.||..|               |.||.|..:.|...|.::                    
Zfish   329 ----GNFGGGGG---------------GGNSGGGGNYNDFGNYNS-------------------- 354

  Fly   445 NQWSLVGNQLQNQNQDQQGGNFLSWMAQNGGHNNANNFGGRKGPNNPNNNPAANGIKTDNSEPQN 509
                      |..|.....|||       ||       |||      |:.|...|....:|....
Zfish   355 ----------QQSNYGPMKGNF-------GG-------GGR------NSGPYGGGYGGGSSGSGG 389

  Fly   510 GNTGWSNQSSG 520
            |.:|:...|.|
Zfish   390 GGSGYGGGSGG 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 28/77 (36%)
RRM2_TDP43 192..261 CDD:409761 25/74 (34%)
hnrnpa1bNP_956398.3 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.