Protein Alignment TBPH and Rbp9

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001259974.1
• Gene: Rbp9 / 33498
• FlyBaseID: FBgn0010263
• Length: 684
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 131/575 - (22%)
• Similarity: 200/575 - (34%)
• Gaps: 176/575 - (30%)

  Fly    72 YAYFCVFPKENKRKSDD-----NLENSTAK---TKRIETRLRCTDLIVLGLPWKTTEESLREYFE 128
            |.:.....:|:..|:.:     .|:|.|.|   .:.....::..:|.|.|||...|:..|...|.
  Fly   153 YGFVNYVKQEDAEKAINALNGLRLQNKTIKVSIARPSSESIKGANLYVSGLPKNMTQSDLESLFS 217

  Fly   129 TYGEVLMAQIKKDTKSGQSKGFGFVRF-------------------------------------- 155
            .||:::.::|..|..:|.|||.||:||
  Fly   218 PYGKIITSRILCDNITGLSKGVGFIRFDQRFEADRAIKELNGTTPKNSTEPITVKFANNPSSNKN 282

  Fly   156 -----GSYDAQMRVLTNR-------------------HLIDGRWCEV----------KVPNSKGM 186
                 .:|.|.......|                   |...||:..|          .:.|....
  Fly   283 SMQPLAAYIAPQNTRGGRAFPANAAAGAAAAAAAAAIHPNAGRYSSVISRYSPLTSDLITNGMIQ 347

  Fly   187 GHQVPCK---VFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPF-----RAFSFVTFLDPDVA-- 241
            |:.:...   :||.....|...:.|.:.|..||.|..|.:.|..     :.|.|||..:.:.|
  Fly   348 GNTIASSGWCIFVYNLAPDTEENVLWQLFGPFGAVQSVKVIRDLQSNKCKGFGFVTMTNYEEAVL 412

  Fly   242 --QSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQ-------VQSYNYN------SANSFGMHSYHP 291
              |||.|  :.:....:.||     .:.|:|:|       ....|.|      :||...:|::|
  Fly   413 AIQSLNG--YTLGNRVLQVS-----FKTNKNKQTXLLTKLAAVVNANAAAAALAANGLVLHNHH- 469

  Fly   292 QGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSG 356
              :|.|.|    ...||.:|::|           ...|.:.:|  .|..:|.....:|..|.:|
  Fly   470 --HHSNIG----SINNNSNNSNG-----------CSAAAFPLG--KYVNHSSNNRQHNINNSTS- 514

  Fly   357 GNTNRQDGGSQYNSRQSNFHGMNQPHN--GNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSN-- 417
             ||::|...|..|.:||    |..|..  .:...:.|       |:....|...:|...|:|:
  Fly   515 -NTSKQKPASTSNKQQS----MAPPKRLASSTAATTG-------DLAATAATNSSSSSHSASSGD 567

  Fly   418 ------QGQNMSNQSMLNLNSLPINPALV-AAALNQWSLVGNQLQNQNQDQQGGNFLSWMA---- 471
                  ...:.|:.|..|.|.|..:...: ....||:.|:..|||.|   |:...||:.:|
  Fly   568 AGATGTAASSSSSSSSTNNNILKTSTKFIYNKPQNQYELLQQQLQLQ---QEFAQFLTNVANSAA 629

  Fly   472 ---QNGGHNNAN--NFGGRKGPN-NPNNNPAANGIKTDNSEPQNGNTG----WSN 516
               .||..|:.|  |.||..|.. ..:.|.|..|....||   |||.|    |||
  Fly   630 TPSSNGSANSTNQRNGGGTIGMGLGMSANSAGGGSGNKNS---NGNNGYMPTWSN 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	1/5 (20%)
		RRM1_TDP43	108..181	CDD:409760	27/144 (19%)
		RRM2_TDP43	192..261	CDD:409761	21/80 (26%)
Rbp9	NP_001259974.1	ELAV_HUD_SF	107..438	CDD:273741	59/291 (20%)