Protein Alignment TBPH and hnrnpa0b

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_999871.1
• Gene: hnrnpa0b / 334222
• ZFINID: ZDB-GENE-030131-6154
• Length: 314
• Species: Danio rerio
• Alignment Length: 303
• Identity: 91/303 - (30%)
• Similarity: 136/303 - (44%)
• Gaps: 39/303 - (12%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFG-SYDAQMRVLTNRHLID 172
            |.|.||..:||.:.||.|||.:|.:....:.::.:..:|:.||||.:. |.:|...:....|::|
Zfish    10 LFVGGLNVQTTNDGLRSYFEQFGNLTDCVVVQNDQLQRSRCFGFVTYSTSEEADAAMAARPHVVD 74

  Fly   173 GRWCEVKVPNSKGMGHQVPC-----KVFVGRCTEDINSDDLREYFSKFG--EVTDVFIPRPF--- 227
            |:..|||...::....:...     |:|||...:||...||.|:||:||  |.::|...:..
Zfish    75 GKNVEVKRAVAREDAGRPEALAKVKKIFVGGLKDDIEEKDLTEFFSQFGMIEKSEVITDKDTGKK 139

  Fly   228 RAFSFVTFLDPDVA-QSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHP 291
            |.|.||.|.|.|.| :::..:.|:|.|..|.|..|..|      |::|:       :.|......
Zfish   140 RGFGFVHFEDNDSADKAVVLKFHMINGHKVEVKKALTK------QEIQA-------AGGARGGRG 191

  Fly   292 QGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYG--MGGNNYGGNSGGGYHNNGGNHS 354
            :|.....|||.:..|..:...:||........:.....|||  .|...|||..||||   ||.:.
Zfish   192 RGGGRGMGRNQNGFGGGRGGGYGGYGGGYGGGYGGNDGGYGGSYGSGGYGGGYGGGY---GGGYG 253

  Fly   355 S-----GGNTNRQDGGSQYNSRQSNFHGMNQPHNGNV-GGSNG 391
            .     ||..:..|.||.|..:.|.:..|.   .||. ||.:|
Zfish   254 EQMGGYGGGNDYSDFGSGYGQQSSGYGPMK---GGNTYGGRSG 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	25/72 (35%)
		RRM2_TDP43	192..261	CDD:409761	28/79 (35%)
hnrnpa0b	NP_999871.1	RRM_SF	6..84	CDD:473069	25/73 (34%)
		RRM_SF	100..179	CDD:473069	30/84 (36%)
		HnRNPA1	263..294	CDD:463312	11/34 (32%)