DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBPH and tardbpb

DIOPT Version :9

Sequence 1:	NP_001163280.1	Gene:	TBPH / 37781	FlyBaseID:	FBgn0025790	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_958884.1	Gene:	tardbpb / 325052	ZFINID:	ZDB-GENE-030131-3777	Length:	412	Species:	Danio rerio

Alignment Length:	452	Identity:	195/452 - (43%)
Similarity:	271/452 - (59%)	Gaps:	77/452 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 FVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVES 67
            :::|:|||.:||:|:|:|:|||:||||:.|||||:|||::|:..::.:||||..:|.|..|  |:
Zfish     5 YIRVAEEENEEPMEIPSEDDGTVLLSTVSAQFPGACGLRFRSPVSQCMRGVRLVDGILHAP--EN 67

  Fly    68 GWGEYAYFCVFPKE-----NKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYF 127
            |||...|...:|||     ||||.|:...:|..|.||.:.  :.:|||||||||||:|:.|::||
Zfish    68 GWGNLVYVVNYPKETVLPDNKRKMDEIDASSATKIKRGDQ--KTSDLIVLGLPWKTSEQDLKDYF 130

  Fly   128 ETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPC 192
            .|:|||:|.|:|:|.|:|.||||||||||.::.|.:|:|.||:||||||:.|:|||| .|...|.
Zfish   131 GTFGEVIMVQVKRDVKTGNSKGFGFVRFGDWETQSKVMTQRHMIDGRWCDCKLPNSK-QGIDEPM 194

  Fly   193 ---KVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGV 254
               ||||||||||:.:|:||::|.::|||||||||:|||||:||||.|..||.:|||||.|||||
Zfish   195 RSRKVFVGRCTEDMTADELRQFFMQYGEVTDVFIPKPFRAFAFVTFADDQVAAALCGEDLIIKGV 259

  Fly   255 SVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAI 319
            |||:|||.||  .|..:|:........|.||...:  .|:..|.|..|           ||.::.
Zfish   260 SVHISNAEPK--HNNTRQMMERAGRFGNGFGGQGF--AGSRSNMGGGG-----------GGSSSS 309

  Fly   320 VPN--NHNIGTA-----------GYGMGG----NNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQ 367
            :.|  |.|:..|           .:||.|    .|..|.||         .|:.|.::.:|....
Zfish   310 LGNFGNFNLNPAMMAAAQAALQSSWGMMGMLAQQNQSGTSG---------TSTSGTSSSRDQAQT 365

  Fly   368 YNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSS---SSNQGQNMSNQS 426
            |:|..||:        |:...:.||            ..|.||..:|   :|:.|.:|.::|
Zfish   366 YSSANSNY--------GSSSAALGW------------GTGSNSGAASAGFNSSFGSSMESKS 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_001163280.1	RRM1_TDP43	108..184	CDD:240767	49/75 (65%)
TBPH	NP_001163280.1	RRM2_TDP43	192..261	CDD:240768	49/71 (69%)
tardbpb	NP_958884.1	RRM	<85..>177	CDD:223796	51/93 (55%)
		RRM1_TDP43	111..187	CDD:240767	49/75 (65%)
		RRM2_TDP43	197..267	CDD:240768	50/69 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596521
Domainoid	1	1.000	90	1.000	Domainoid score	I7761
eggNOG	1	0.900	-	-		E1_28HBV
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	332	1.000	Inparanoid score	I2410
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1425837at2759
OrthoFinder	1	1.000	-	-		FOG0005498
OrthoInspector	1	1.000	-	-		mtm6337
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48033
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3916
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860