Protein Alignment TBPH and HNRNPD

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_112738.1
• Gene: HNRNPD / 3184
• HGNCID: 5036
• Length: 355
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 86/310 - (27%)
• Similarity: 139/310 - (44%)
• Gaps: 34/310 - (10%)

  Fly    82 NKRKSDDNLENSTAKTKRIETRLRCT-DLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSG 145
            :|.:.|:...||:.:.....|..|.. .:.:.||.|.||::.|::||..:|||:...:|.|..:|
Human    71 SKNEEDEGHSNSSPRHSEAATAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITG 135

  Fly   146 QSKGFGFVRFGSYDAQMRVLTNR-HLIDGRWCEVKVPNSKGMGHQVPC-KVFVGRCTEDINSDDL 208
            :|:|||||.|...::..:|:..: |.::|:..:.|  .:|.|..:.|. |:|||..:.|...:.:
Human   136 RSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPK--RAKAMKTKEPVKKIFVGGLSPDTPEEKI 198

  Fly   209 REYFSKFGEVTDVFIP-----RPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHVSNAAPKAEQN 268
            ||||..||||..:.:|     ...|.|.|:||.:.:..:.:..:    |..:|.:|....|...:
Human   199 REYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEK----KYHNVGLSKCEIKVAMS 259

  Fly   269 RNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGM 333
            :.|..|...:.|...|.             ||.....|....|.:.|.:    |..|.|...||.
Human   260 KEQYQQQQQWGSRGGFA-------------GRARGRGGGPSQNWNQGYS----NYWNQGYGNYGY 307

  Fly   334 GGNNYGGNSGGGYHNNGGNHSSG-GNTNRQDGGSQYNSRQSNFHGMNQPH 382
            ....|||.  |||...|.|:..| |:.:.|..|....||:.......:|:
Human   308 NSQGYGGY--GGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	25/73 (34%)
		RRM2_TDP43	192..261	CDD:409761	22/74 (30%)
HNRNPD	NP_112738.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..92		4/20 (20%)
		CBFNT	<60..78	CDD:311868	2/6 (33%)
		RRM1_hnRNPD	99..172	CDD:410150	25/74 (34%)
		RRM2_hnRNPD	183..257	CDD:241027	23/77 (30%)