Protein Alignment TBPH and HNRNPAB

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_112556.2
• Gene: HNRNPAB / 3182
• HGNCID: 5034
• Length: 332
• Species: Homo sapiens
• Alignment Length: 384
• Identity: 106/384 - (27%)
• Similarity: 162/384 - (42%)
• Gaps: 76/384 - (19%)

  Fly     6 VSEEEGDEPIELP-AEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVESGW 69
            :||...::|:|.. |.|:|...:.  :.:.|...|       |.|..|  :......|||.....
Human     1 MSEAGEEQPMETTGATENGHEAVP--EGESPAGAG-------TGAAAG--AGGATAAPPSGNQNG 54

  Fly    70 GEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVL 134
            .|      ..:.|..|::::                ...:.|.||.|.|:::.|::||..:|||:
Human    55 AE------GDQINASKNEED----------------AGKMFVGGLSWDTSKKDLKDYFTKFGEVV 97

  Fly   135 MAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNR-HLIDGRWCEVKVPNSKGMGHQVPCKVFVGR 198
            ...||.|..:|:|:||||:.|....:..:||..: |.:|||..:.|  .:..|......|:|||.
Human    98 DCTIKMDPNTGRSRGFGFILFKDAASVEKVLDQKEHRLDGRVIDPK--KAMAMKKDPVKKIFVGG 160

  Fly   199 CTEDINSDDLREYFSKFGEVTDVFIP-----RPFRAFSFVTFLDPD-VAQSLCGEDHIIKGVSVH 257
            ...:...:.:||||.:|||:..:.:|     ...|.|.|:||.:.: |.:.|..:.|.:.|....
Human   161 LNPEATEEKIREYFGEFGEIEAIELPMDPKLNKRRGFVFITFKEEEPVKKVLEKKFHTVSGSKCE 225

  Fly   258 VSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGE----NA 318
            :..|.||      :..|...|.|..         :||     ||..:||:......||:    |.
Human   226 IKVAQPK------EVYQQQQYGSGG---------RGN-----RNRGNRGSGGGGGGGGQSQSWNQ 270

  Fly   319 IVPNNHNIGTAGYGMG-GNNYGG--NSGGGYHNNG-GNHSSGGNTN----RQDGGSQYN 369
            ...|..|.| .||..| |..|||  .|..||:..| |...|.|:||    ::.||.|.|
Human   271 GYGNYWNQG-YGYQQGYGPGYGGYDYSPYGYYGYGPGYDYSQGSTNYGKSQRRGGHQNN 328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	16/72 (22%)
		RRM1_TDP43	108..181	CDD:409760	28/73 (38%)
		RRM2_TDP43	192..261	CDD:409761	21/74 (28%)
HNRNPAB	NP_112556.2	CBFNT	1..70	CDD:311868	18/101 (18%)
		RRM1_hnRNPAB	66..145	CDD:410151	28/96 (29%)
		RRM2_hnRNPAB	150..229	CDD:409997	21/78 (27%)