DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and HNRNPA1

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_112420.1 Gene:HNRNPA1 / 3178 HGNCID:5031 Length:372 Species:Homo sapiens


Alignment Length:441 Identity:126/441 - (28%)
Similarity:175/441 - (39%) Gaps:91/441 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 STAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGS 157
            |.:::.:...:||  .|.:.||.::||:||||.:||.:|.:....:.:|..:.:|:|||||.:.:
Human     2 SKSESPKEPEQLR--KLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYAT 64

  Fly   158 ---YDAQMRVLTNRHLIDGRWCE----VKVPNSKGMG-HQVPCKVFVGRCTEDINSDDLREYFSK 214
               .||.|.  ...|.:|||..|    |...:|:..| |....|:|||...||.....||:||.:
Human    65 VEEVDAAMN--ARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQ 127

  Fly   215 FG--EVTDVFIPR---PFRAFSFVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQV 273
            :|  ||.::...|   ..|.|:||||.|.| |.:.:..:.|.:.|.:..|..|..|.|.......
Human   128 YGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSS 192

  Fly   274 QSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNY 338
            |.....|.| ||.......|.:.|.||.|:..|   ....||..         |..|||..|:.|
Human   193 QRGRSGSGN-FGGGRGGGFGGNDNFGRGGNFSG---RGGFGGSR---------GGGGYGGSGDGY 244

  Fly   339 GGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNL 403
            .|....|.:..||...|||:.....||..|.::.|.:.|.....:.|.||..|:           
Human   245 NGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGF----------- 298

  Fly   404 QALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQQGGNFLS 468
                   .|.|.||.|...|.....|.|             ||.|..|        ..:||||  
Human   299 -------GGGSGSNFGGGGSYNDFGNYN-------------NQSSNFG--------PMKGGNF-- 333

  Fly   469 WMAQNGGHNNANNFGGRKGPNNPNNNPAANGIKTDNSEPQNGNTGWSNQSS 519
                 ||.::....||.:....|.|              |.|..|.|:.||
Human   334 -----GGRSSGPYGGGGQYFAKPRN--------------QGGYGGSSSSSS 365

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 28/79 (35%)
RRM2_TDP43 192..261 CDD:409761 26/74 (35%)
HNRNPA1NP_112420.1 Globular A domain 4..94 30/93 (32%)
RRM1_hnRNPA1 12..92 CDD:410154 30/83 (36%)
Globular B domain 95..185 31/89 (35%)
RRM2_hnRNPA3 105..184 CDD:409996 27/78 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..216 8/34 (24%)
RNA-binding RGG-box 218..240 9/33 (27%)
HnRNPA1 312..344 CDD:463312 12/59 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..372 22/91 (24%)
Nuclear targeting sequence (M9) 320..357 15/65 (23%)
Blue background indicates that the domain is not in the aligned region.

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