Protein Alignment TBPH and Rbm31y

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_001395831.1
• Gene: Rbm31y / 302780
• RGDID: 1562219
• Length: 565
• Species: Rattus norvegicus
• Alignment Length: 513
• Identity: 125/513 - (24%)
• Similarity: 185/513 - (36%)
• Gaps: 126/513 - (24%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL-TNRHLID 172
            :.:.||..:..::.|.||...:||::...||.|..:|.|:|||||.|.......:|| ...|.:|
  Rat    35 MFIGGLSQELNKQVLLEYLSKFGEIIDFIIKIDPNTGLSRGFGFVLFKDSSTVEKVLRVKDHKVD 99

  Fly   173 GRWCEVKVPNSKGMGHQVPC-KVFVGRCTEDINSDDLREYFSKFGEVTDVFIP-----RPFRAFS 231
            |:..|.|  .:|.:..|.|. |||||.....::.:.:|.||..||::..:.:|     :..|||.
  Rat   100 GKKIEFK--RAKALESQFPIKKVFVGGLNPRMSEEKIRAYFGTFGQIEAIELPLCSDTQERRAFG 162

  Fly   232 FVTFLDPD-VAQSLCGEDHIIKGVSVHVSNAAPK---AEQNRNQQVQSYN-----------YNSA 281
            |:.::|.: |.:.|....|.|......|..|.||   |.|....:.::.:           .|..
  Rat   163 FIKYMDENPVRKVLETRYHFIGSSRCEVKMAFPKEYPARQLSKSKTRAKDRARTAVPAAELENHW 227

  Fly   282 NSFGMHSYHPQGNH--MNPGRNGHHRGN---------NQHNAHG----------GENAIVPN--- 322
            ...|..::|...|.  ....::.|..|:         ...||.|          ..|.||.|
  Rat   228 RGGGSQNFHIMDNSDTQEANQDAHRAGSYTSRANSDVTLSNARGFRDTPNAFQANPNVIVTNSSA 292

  Fly   323 -----------NHNIGTAGYGMG-------GNNYGGNSGGGYHN--NGGNHSSGGNTNRQDGGSQ 367
                       ::.:|.:.|.:|       .|.|   :.|...|  ....::.|...|.. |.||
  Rat   293 FRASRTALRPISNTVGLSHYALGANPNAFLANQY---TFGAIPNALRTSQYTLGTYPNAL-GVSQ 353

  Fly   368 YN-SRQSNFHGMNQ---PHNGNVGGSNGWMNRGHL-DMPNLQALGINSQGSSSSNQGQNM--SNQ 425
            |. :...|..|:||   ..|.||    .|.|:..| ..|:  |.||   |..:.|...|:  :||
  Rat   354 YALAAYPNAFGINQCTLGANPNV----FWTNQYPLGTYPD--AFGI---GQYAWNMSPNVFGANQ 409

  Fly   426 SMLNLNSLPINPALVAAALNQWSLVGNQ---LQNQNQDQQGGNFLSWMAQNGGHNNANNFGGRK- 486
            ..|..||....|...:...|.:.:..|.   ..|.|..:.....|.        .|.|.||...
  Rat   410 YTLGTNSDAFRPNCYSFVANPYDIRTNHYVLATNPNVSRTSQYILG--------ANPNAFGSSHY 466

  Fly   487 ---------GPNNPNNNPAANGIKTDNSEPQNGN----TGWSNQSSGSQNAAEKSNFL 531
                     |||             .:|...|||    .|.|..:.|...:....|||
  Rat   467 SVGASQNVFGPN-------------QHSFGVNGNFCGAAGSSGGTGGFNFSQVYGNFL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	25/72 (35%)
		RRM2_TDP43	192..261	CDD:409761	21/75 (28%)
Rbm31y	NP_001395831.1	RRM_SF	34..109	CDD:473069	25/75 (33%)
		RRM_SF	116..193	CDD:473069	22/76 (29%)