Protein Alignment TBPH and DAZAP1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: XP_011526206.1
• Gene: DAZAP1 / 26528
• HGNCID: 2683
• Length: 550
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 88/273 - (32%)
• Similarity: 117/273 - (42%)
• Gaps: 73/273 - (26%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNR-HLID 172
            |.|.||.|.||:|:||.||..||||:...|.||..:.||:|||||:|...:....||.:| |.:|
Human   155 LFVGGLDWSTTQETLRSYFSQYGEVVDCVIMKDKTTNQSRGFGFVKFKDPNCVGTVLASRPHTLD 219

  Fly   173 GRWCEVKVPNSKGM-----------------GHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTD 220
            ||..:.|....:||                 .:....|:|||....:....:|||||.|||.||:
Human   220 GRNIDPKPCTPRGMQPERTRPKEGWQKGPRSDNSKSNKIFVGGIPHNCGETELREYFKKFGVVTE 284

  Fly   221 VFI------PRPFRAFSFVTFLD-PDVAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNY 278
            |.:      .|| |.|.|:||.| ..|.|::....|.|.|..|.|..|.|     |:.:.|:
Human   285 VVMIYDAEKQRP-RGFGFITFEDEQSVDQAVNMHFHDIMGKKVEVKRAEP-----RDSKSQA--- 340

  Fly   279 NSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTA---------GYGMG 334
                               ||:.|..:..::         :|||..| |.|         |||..
Human   341 -------------------PGQPGASQWGSR---------VVPNAAN-GWAGQPPPTWQQGYGPQ 376

  Fly   335 GNNY-GGNSGGGY 346
            |... .|.:.|||
Human   377 GMWVPAGQAIGGY 389

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	35/72 (49%)
		RRM2_TDP43	192..261	CDD:409761	30/75 (40%)
DAZAP1	XP_011526206.1	ELAV_HUD_SF	<106..199	CDD:273741	24/43 (56%)
		RRM1_DAZAP1	154..235	CDD:409988	37/79 (47%)
		RRM2_DAZAP1	254..333	CDD:409765	31/79 (39%)