Protein Alignment TBPH and Msi1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_683688.1
• Gene: Msi1 / 259272
• RGDID: 628778
• Length: 362
• Species: Rattus norvegicus
• Alignment Length: 248
• Identity: 68/248 - (27%)
• Similarity: 105/248 - (42%)
• Gaps: 46/248 - (18%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLT-NRHLID 172
            :.:.||.|:||:|.|||||..:|||....:.:|..:.:|:|||||.|.......:||. :||.:|
  Rat    22 MFIGGLSWQTTQEGLREYFGQFGEVKECLVMRDPLTKRSRGFGFVTFMDQAGVDKVLAQSRHELD 86

  Fly   173 GRWCEVKVPNSKGMGHQVPC---KVFVGRCTEDINSDDLREYFSKFGEVTDVFI-----PRPFRA 229
            .:..:.||...:....::..   |:|||..:.:...:|::.||.:||:|.|..:     ....|.
  Rat    87 SKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSVNTTVEDVKHYFEQFGKVDDAMLMFDKTTNRHRG 151

  Fly   230 FSFVTFLDPDVAQSLCG-EDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQG 293
            |.||||...|:.:.:|. ..|.|....|....|.||
  Rat   152 FGFVTFESEDIVEKVCEIHFHEINNKMVECKKAQPK----------------------------- 187

  Fly   294 NHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGY-GMGGNNYGGNSGGG 345
            ..|:|  .|..||.::...:|.:..::    .||..|| |.....|...|..|
  Rat   188 EVMSP--TGSARGRSRVMPYGMDAFML----GIGMLGYPGFQATTYASRSYTG 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	28/72 (39%)
		RRM2_TDP43	192..261	CDD:409761	22/77 (29%)
Msi1	NP_683688.1	RRM1_MSI	21..96	CDD:409990	29/73 (40%)
		PABP-1234	<32..339	CDD:130689	64/238 (27%)
		RRM2_MSI	110..183	CDD:240769	22/72 (31%)