DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and Ncl

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_036881.2 Gene:Ncl / 25135 RGDID:3153 Length:714 Species:Rattus norvegicus


Alignment Length:393 Identity:87/393 - (22%)
Similarity:133/393 - (33%) Gaps:127/393 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 VSEEEGDEPIELPAE-----EDGTLLLSTLQAQFPGSCGLKY----------RNLDTKAVRGVRS 55
            ::|:|..|..|...|     :||.            |.|:.|          :||:.|....:..
  Rat   409 ITEDELKEVFEDAVEIRLVSQDGR------------SKGIAYIEFKSEADAEKNLEEKQGAEIDG 461

  Fly    56 NEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENST----AKTKRIETRLRCTDLIVLGLPW 116
            ....|:                :..|..::.:...:|||    :||           |::..|.:
  Rat   462 RSVSLY----------------YTGEKGQRQERTGKNSTWSGESKT-----------LVLSNLSY 499

  Fly   117 KTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLT--NRHLIDGRWCEVK 179
            ..|||:|:|.||....:.:.|    ...|:|||:.|:.|.|::.....|.  |:..|:||...::
  Rat   500 SATEETLQEVFEKATFIKVPQ----NPHGKSKGYAFIEFASFEDAKEALNSCNKMEIEGRTIRLE 560

  Fly   180 VPNSKGM--GHQVPCK-VFVGRCTEDINSDDLREYFSKFGEVTDVFI----PRPFRAFSFVTFLD 237
            :...:|.  ....|.| :||...:||...:.|:|.|.  |.|....:    ....:.|.||.|..
  Rat   561 LQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFE--GSVRARIVTDRETGSSKGFGFVDFNS 623

  Fly   238 PDVAQSL--CGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGR 300
            .:.|::.  ..||..|.|..|.:..|.||.|               ..||             ||
  Rat   624 EEDAKAAKEAMEDGEIDGNKVTLDWAKPKGE---------------GGFG-------------GR 660

  Fly   301 NGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGG 365
            .|                        |..|:|..|...||..|.|....||....||....:.||
  Rat   661 GG------------------------GRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGG 701

  Fly   366 SQY 368
            ..:
  Rat   702 GDF 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833 14/86 (16%)
RRM1_TDP43 108..181 CDD:409760 22/74 (30%)
RRM2_TDP43 192..261 CDD:409761 20/75 (27%)
NclNP_036881.2 8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X 58..135
RRM1_NCL 312..386 CDD:409837
RRM2_NCL 395..470 CDD:409838 14/88 (16%)
RRM3_NCL 489..561 CDD:409839 24/86 (28%)
RRM4_NCL 576..653 CDD:409840 22/78 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..714 23/111 (21%)
Blue background indicates that the domain is not in the aligned region.

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