| Sequence 1: | NP_001163280.1 | Gene: | TBPH / 37781 | FlyBaseID: | FBgn0025790 | Length: | 531 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_031401.1 | Gene: | TARDBP / 23435 | HGNCID: | 11571 | Length: | 414 | Species: | Homo sapiens |
| Alignment Length: | 535 | Identity: | 215/535 - (40%) |
|---|---|---|---|
| Similarity: | 283/535 - (52%) | Gaps: | 157/535 - (29%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 2 DFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVE 66
Fly 67 SGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYG 131
Fly 132 EVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVPC---K 193
Fly 194 VFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHV 258
Fly 259 SNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNN 323
Fly 324 HNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGG 388
Fly 389 SNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAA----LNQWSL 449
Fly 450 VGNQLQNQNQDQQGGNFLSWMAQNGGH-----NNANNFGGRKGPNNPNNNPAANGIKTDNSEPQN 509
Fly 510 GNTGW---SNQSSGS 521 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| TBPH | NP_001163280.1 | RRM1_TDP43 | 108..184 | CDD:240767 | 52/75 (69%) |
| RRM2_TDP43 | 192..261 | CDD:240768 | 49/71 (69%) | ||
| TARDBP | NP_031401.1 | TDP43_N | 4..77 | CDD:376118 | 40/74 (54%) |
| Nuclear localization signal. /evidence=ECO:0000269|PubMed:18957508 | 82..98 | 6/15 (40%) | |||
| RRM1_TDP43 | 105..181 | CDD:240767 | 52/75 (69%) | ||
| RRM2_TDP43 | 191..261 | CDD:240768 | 50/69 (72%) | ||
| Interaction with UBQLN2. /evidence=ECO:0000269|PubMed:23541532 | 216..414 | 92/317 (29%) | |||
| Nuclear export signal. /evidence=ECO:0000269|PubMed:18957508 | 239..250 | 8/10 (80%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 261..303 | 21/155 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 341..373 | 12/38 (32%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165160179 | |
| Domainoid | 1 | 1.000 | 92 | 1.000 | Domainoid score | I7661 |
| eggNOG | 1 | 0.900 | - | - | E1_28HBV | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 352 | 1.000 | Inparanoid score | I2270 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1962 |
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1425837at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0005498 | |
| OrthoInspector | 1 | 1.000 | - | - | otm40817 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_105367 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR48033 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R3811 |
| SonicParanoid | 1 | 1.000 | - | - | X3916 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 15 | 14.740 | |||||