DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and Tardbp

DIOPT Version :9

Sequence 1:NP_001163280.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:NP_663531.1 Gene:Tardbp / 230908 MGIID:2387629 Length:414 Species:Mus musculus


Alignment Length:540 Identity:211/540 - (39%)
Similarity:283/540 - (52%) Gaps:152/540 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVE 66
            ::::|:|:|.|||||:|:|:|||:||||:.|||||:|||:|||..::.:||||..||.|..|  :
Mouse     3 EYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP--D 65

  Fly    67 SGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYG 131
            :|||...|...:||:||||.|:...:|..|.||...  :.:|||||||||||||:.|::||.|:|
Mouse    66 AGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQ--KTSDLIVLGLPWKTTEQDLKDYFSTFG 128

  Fly   132 EVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVP----- 191
            ||||.|:|||.|:|.|||||||||..|:.|::|::.||:||||||:.|:||||    |.|     
Mouse   129 EVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK----QSPDEPLR 189

  Fly   192 -CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVS 255
             .||||||||||:.:::|:::|.::|||.|||||:|||||:||||.|..|||||||||.||||:|
Mouse   190 SRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGIS 254

  Fly   256 VHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIV 320
            ||:|||.||  .|.|:|::     .:..||          .|||..|:..|..  |:.||     
Mouse   255 VHISNAEPK--HNSNRQLE-----RSGRFG----------GNPGGFGNQGGFG--NSRGG----- 295

  Fly   321 PNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGN 385
                     |.|: |||.|||.|||                                        
Mouse   296 ---------GAGL-GNNQGGNMGGG---------------------------------------- 310

  Fly   386 VGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAA----LNQ 446
                                                      :|..:..||||::|||    .:.
Mouse   311 ------------------------------------------MNFGAFSINPAMMAAAQAALQSS 333

  Fly   447 WSLVGNQLQNQNQDQQGGNFLSW--------MAQNGGHN--NANNFGGRKGPNNPNNNPAANGIK 501
            |.::|.....|||....||..|.        .|...|:|  :.:|.|...|..:.:|..:.:|. 
Mouse   334 WGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGF- 397

  Fly   502 TDNSEPQNGNTGWSNQSSGS 521
                   ||..|.|..|..|
Mouse   398 -------NGGFGSSMDSKSS 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_001163280.1 RRM1_TDP43 108..184 CDD:240767 51/75 (68%)
RRM2_TDP43 192..261 CDD:240768 47/68 (69%)
TardbpNP_663531.1 TDP43_N 4..77 CDD:408471 40/74 (54%)
RRM1_TDP43 105..178 CDD:409760 49/72 (68%)
RRM2_TDP43 191..261 CDD:409761 48/69 (70%)
Interaction with UBQLN2. /evidence=ECO:0000250|UniProtKB:Q13148 216..414 92/319 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 261..301 17/73 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 341..414 20/78 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167850553
Domainoid 1 1.000 91 1.000 Domainoid score I7697
eggNOG 1 0.900 - - E1_28HBV
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 346 1.000 Inparanoid score I2294
Isobase 1 0.950 - 0 Normalized mean entropy S1962
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005498
OrthoInspector 1 1.000 - - otm42894
orthoMCL 1 0.900 - - OOG6_105367
Panther 1 1.100 - - LDO PTHR48033
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3811
SonicParanoid 1 1.000 - - X3916
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.730

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