Protein Alignment TBPH and Tardbp

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_663531.1
• Gene: Tardbp / 230908
• MGIID: 2387629
• Length: 414
• Species: Mus musculus
• Alignment Length: 540
• Identity: 211/540 - (39%)
• Similarity: 283/540 - (52%)
• Gaps: 152/540 - (28%)

  Fly     2 DFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEGRLFPPSVE 66
            ::::|:|:|.|||||:|:|:|||:||||:.|||||:|||:|||..::.:||||..||.|..|  :
Mouse     3 EYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAP--D 65

  Fly    67 SGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWKTTEESLREYFETYG 131
            :|||...|...:||:||||.|:...:|..|.||...  :.:|||||||||||||:.|::||.|:|
Mouse    66 AGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQ--KTSDLIVLGLPWKTTEQDLKDYFSTFG 128

  Fly   132 EVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTNRHLIDGRWCEVKVPNSKGMGHQVP----- 191
            ||||.|:|||.|:|.|||||||||..|:.|::|::.||:||||||:.|:||||    |.|
Mouse   129 EVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSK----QSPDEPLR 189

  Fly   192 -CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVS 255
             .||||||||||:.:::|:::|.::|||.|||||:|||||:||||.|..|||||||||.||||:|
Mouse   190 SRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGIS 254

  Fly   256 VHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIV 320
            ||:|||.||  .|.|:|::     .:..||          .|||..|:..|..  |:.||
Mouse   255 VHISNAEPK--HNSNRQLE-----RSGRFG----------GNPGGFGNQGGFG--NSRGG----- 295

  Fly   321 PNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGN 385
                     |.|: |||.|||.|||
Mouse   296 ---------GAGL-GNNQGGNMGGG---------------------------------------- 310

  Fly   386 VGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSMLNLNSLPINPALVAAA----LNQ 446
                                                      :|..:..||||::|||    .:.
Mouse   311 ------------------------------------------MNFGAFSINPAMMAAAQAALQSS 333

  Fly   447 WSLVGNQLQNQNQDQQGGNFLSW--------MAQNGGHN--NANNFGGRKGPNNPNNNPAANGIK 501
            |.::|.....|||....||..|.        .|...|:|  :.:|.|...|..:.:|..:.:|.
Mouse   334 WGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGF- 397

  Fly   502 TDNSEPQNGNTGWSNQSSGS 521
                   ||..|.|..|..|
Mouse   398 -------NGGFGSSMDSKSS 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	40/74 (54%)
		RRM1_TDP43	108..181	CDD:409760	49/72 (68%)
		RRM2_TDP43	192..261	CDD:409761	47/68 (69%)
Tardbp	NP_663531.1	TDP43_N	4..77	CDD:465833	40/74 (54%)
		RRM1_TDP43	105..178	CDD:409760	49/72 (68%)
		RRM2_TDP43	191..261	CDD:409761	48/69 (70%)
		Interaction with UBQLN2. /evidence=ECO:0000250|UniProtKB:Q13148	216..414		92/319 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..301		17/73 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..414		20/78 (26%)