Protein Alignment TBPH and HNRNPA3

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_919223.1
• Gene: HNRNPA3 / 220988
• HGNCID: 24941
• Length: 378
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 126/484 - (26%)
• Similarity: 177/484 - (36%)
• Gaps: 130/484 - (26%)

  Fly    53 VRSNEGRLFPPSVESGWGEYAYFCVFPKENKRKSDDNLENSTAKTKRIETRLRCTDLIVLGLPWK 117
            |:...||   |..:||           :..:|:.::..:....:..|        .|.:.||.::
Human     3 VKPPPGR---PQPDSG-----------RRRRRRGEEGHDPKEPEQLR--------KLFIGGLSFE 45

  Fly   118 TTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFG---SYDAQMRVLTNRHLIDGRWCEVK 179
            ||::||||:||.:|.:....:.:|.::.:|:|||||.:.   ..||.|  ....|.:|||..|.|
Human    46 TTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEEVDAAM--CARPHKVDGRVVEPK 108

  Fly   180 VPNS-----KGMGHQVPCKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPR-----PFRAFSFVT 234
            ...|     |...|....|:|||...||....:||:||.|:|::..:.:..     ..|.|:|||
Human   109 RAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIETIEVMEDRQSGKKRGFAFVT 173

  Fly   235 FLDPDVAQSLCGED-HIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGNHMNP 298
            |.|.|....:..:. |.|.|.:..|..|..|      |::||.........|      .||.|
Human   174 FDDHDTVDKIVVQKYHTINGHNCEVKKALSK------QEMQSAGSQRGRGGG------SGNFM-- 224

  Fly   299 GRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNTNRQD 363
            ||.|:..|...:...||...        |..|||.||....|:.|||   :||.:..||:.....
Human   225 GRGGNFGGGGGNFGRGGNFG--------GRGGYGGGGGGSRGSYGGG---DGGYNGFGGDGGNYG 278

  Fly   364 GGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNMSNQSML 428
            ||..|:||..  :|...|..||.||..|                 ...|....|:|.|..
Human   279 GGPGYSSRGG--YGGGGPGYGNQGGGYG-----------------GGGGYDGYNEGGNFG----- 319

  Fly   429 NLNSLPINPALVAAALNQWSLVGNQLQNQNQDQQGGNFLSWMAQNGGHNNANNFGGRKGPNNPNN 493
                                              |||:       ||..|.|:||...|....|.
Human   320 ----------------------------------GGNY-------GGGGNYNDFGNYSGQQQSNY 343

  Fly   494 NPAANGI--KTDNSEPQNGNTGWSNQSSG 520
            .|...|.  ...:..|..|..|....|.|
Human   344 GPMKGGSFGGRSSGSPYGGGYGSGGGSGG 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	6/24 (25%)
		RRM1_TDP43	108..181	CDD:409760	28/75 (37%)
		RRM2_TDP43	192..261	CDD:409761	24/74 (32%)
HNRNPA3	NP_919223.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		7/44 (16%)
		RRM1_hnRNPA_like	36..113	CDD:409992	28/78 (36%)
		RRM2_hnRNPA3	126..205	CDD:409996	26/84 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	204..225		8/34 (24%)
		HnRNPA1	331..>347	CDD:463312	5/15 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	336..378		9/37 (24%)