Protein Alignment TBPH and hrpa-2

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_741783.1
• Gene: hrpa-2 / 180791
• WormBaseID: WBGene00019249
• Length: 336
• Species: Caenorhabditis elegans
• Alignment Length: 311
• Identity: 67/311 - (21%)
• Similarity: 111/311 - (35%)
• Gaps: 80/311 - (25%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGS-YDAQMRVLTNRHLID 172
            |.:.||...||:|.|..||..:|.|:.|.:.:|..:..|:|||||.|.| :.|:..:....|.:.
 Worm    72 LFIGGLSHDTTDEQLGNYFSQWGPVVDAIVIRDPNTKHSRGFGFVTFASIFSAESAMNDRPHKLG 136

  Fly   173 GRWCEVK--VPNSKGMGHQVP-----------CKVFVGRCTEDINS-DDLREYFSKFGEVTDVFI 223
            |:..:.|  :|..: |...:|           ||:.:...|..::| |.||.||..||.:..|.|
 Worm   137 GKTVDSKRAIPREQ-MSSMIPPPFFETDPAPGCKLLLNGITNGVHSVDSLRVYFETFGTLDQVEI 200

  Fly   224 PRPFRAFSFVTFLDPDVAQSLCGED---HIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFG 285
            ....|...||.:.|.:.|......:   ||:....:.|.
 Worm   201 LGQPRGLGFVIYEDKESADRCLAHNSGRHIVNERKIEVR-------------------------- 239

  Fly   286 MHSYHPQGN--HMNPGRNGHHR--------------GNNQHNAHGGENAIVPNNHNIGTAGYGMG 334
            :.:.||.|:  ...|....|.:              |:.:...:....|..|.|.:        .
 Worm   240 VFTKHPNGSTYWKRPQSQSHSQRDLFEQLSQLNLKDGDRKSTGNSSSAADTPQNFD--------E 296

  Fly   335 GNNYGGNSGGGYHNNGGNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGN 385
            .:||||.:         ..........::|.|:.:|.:....  |:..|.:
 Worm   297 DSNYGGTT---------TEDDCNVFEHEEGSSEESSTEQTLE--NEKENSD 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	25/74 (34%)
		RRM2_TDP43	192..261	CDD:409761	21/72 (29%)
hrpa-2	NP_741783.1	RRM_SF	71..148	CDD:473069	25/75 (33%)
		PABP-1234	72..>244	CDD:130689	49/198 (25%)