Protein Alignment TBPH and Ncl

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_035010.3
• Gene: Ncl / 17975
• MGIID: 97286
• Length: 707
• Species: Mus musculus
• Alignment Length: 269
• Identity: 65/269 - (24%)
• Similarity: 95/269 - (35%)
• Gaps: 69/269 - (25%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLT--NRHLI 171
            |::..|.:..|:|:|.|.||....:.:.|    ...|:.||:.|:.|.|::.....|.  |:..|
Mouse   489 LVLSNLSYSATKETLEEVFEKATFIKVPQ----NPHGKPKGYAFIEFASFEDAKEALNSCNKMEI 549

  Fly   172 DGRWCEVKVPNSKGMGHQVPCK-VFVGRCTEDINSDDLREYFSKFGEVTDVFI----PRPFRAFS 231
            :||...:::..|.....  |.| :||...:||...:.|:|.|.  |.|....:    ....:.|.
Mouse   550 EGRTIRLELQGSNSRSQ--PSKTLFVKGLSEDTTEETLKESFE--GSVRARIVTDRETGSSKGFG 610

  Fly   232 FVTFLDPDVAQSL--CGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQGN 294
            ||.|...:.|::.  ..||..|.|..|.:..|.||.|               ..||
Mouse   611 FVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGE---------------GGFG--------- 651

  Fly   295 HMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGNHSSGGNT 359
                ||.|                        |..|:|..|...||..|.|....||....||..
Mouse   652 ----GRGG------------------------GRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFR 688

  Fly   360 NRQDGGSQY 368
            ..:.||..:
Mouse   689 GGRGGGGDF 697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	20/73 (27%)
		RRM2_TDP43	192..261	CDD:409761	20/75 (27%)
Ncl	NP_035010.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..308
		PRK13808	<12..142	CDD:172341
		8 X 8 AA tandem repeats of X-T-P-X-K-K-X-X	58..135
		RRM1_NCL	309..383	CDD:409837
		RRM2_NCL	392..467	CDD:409838
		RRM3_NCL	486..558	CDD:409839	20/72 (28%)
		RRM4_NCL	569..646	CDD:409840	22/78 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	639..707		23/111 (21%)