Protein Alignment TBPH and tiar-2

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_496718.1
• Gene: tiar-2 / 174909
• WormBaseID: WBGene00012904
• Length: 434
• Species: Caenorhabditis elegans
• Alignment Length: 477
• Identity: 113/477 - (23%)
• Similarity: 158/477 - (33%)
• Gaps: 170/477 - (35%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL---TNRHL 170
            |.|..|....|:|.|...|...|.|:.|:|   ...|.:..:.||.|..::.....|   ..|.|
 Worm    42 LFVANLDPAITDEFLATLFNQIGAVMKAKI---IFEGLNDPYAFVEFSDHNQATLALQSHNGREL 103

  Fly   171 IDGRWCEVKV-----PNSKGMGHQVP-----CKVFVGRCTEDINSDDLREYFSKFGEVTDVFIPR 225
            ::.   |:.|     |...|.....|     ..||||....:|:|..|||.|.|||||::..|.|
 Worm   104 LEK---EMHVTWAFEPREPGENRSKPETSRHFHVFVGDLCSEIDSTKLREAFVKFGEVSEAKIIR 165

  Fly   226 -----PFRAFSFVTFLDPDVAQSLCGEDHIIKGV-----SVHVSNAAPKAEQN------------ 268
                 ..:.:.||::...:.|:....|   :.|.     ::..:.|..|.:::
 Worm   166 DNNTNKGKGYGFVSYPRREDAERAIDE---MNGAWLGRRTIRTNWATRKPDEDGERGGDRGDRRG 227

  Fly   269 ---------RNQQVQSYN--YNSANSFGMHSYHPQGNHMNPGRNGHHRGNNQ------------- 309
                     .||..::|:  :|.|.:.....|  .||..|.|.:...|..::
 Worm   228 GGGGGRDRYHNQSEKTYDEIFNQAAADNTSVY--VGNIANLGEDEIRRAFDRFGPINEVRTFKIQ 290

  Fly   310 -------HNAHGGENAIVP-NNHNIG----------------TAGYGMGGNNYGGNSGGGYHNNG 350
                   ........|||. ||.:||                .:..|.||....||.|.||.|:|
 Worm   291 GYAFVKFETKESAARAIVQMNNADIGGQIVRCSWGKSGDSGKPSERGSGGGGGSGNYGYGYGNSG 355

  Fly   351 GNHSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSS 415
            |...|||     .|.||:    |||: ...|.:|| |||.|                    ||.
 Worm   356 GGGGSGG-----PGNSQF----SNFN-QRPPPSGN-GGSGG--------------------GSG- 388

  Fly   416 SNQGQNMSNQSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQQGGNFLSWMAQNGGHNNAN 480
               |||  ||.....:....||.|    :.||                                |
 Worm   389 ---GQN--NQYWQYYSQYYNNPHL----MQQW--------------------------------N 412

  Fly   481 NFGGRKGPNNPNNNPAANGIKT 502
            |:..:.||..|   |||....|
 Worm   413 NYWQKDGPPPP---PAAAASST 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	20/79 (25%)
		RRM2_TDP43	192..261	CDD:409761	22/78 (28%)
tiar-2	NP_496718.1	PABP-1234	41..>317	CDD:130689	64/285 (22%)
		RRM_SF	133..207	CDD:473069	22/76 (29%)
		RRM3_TIA1_like	256..325	CDD:409790	13/70 (19%)