DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TBPH and tdp-1

DIOPT Version :9

Sequence 1:	NP_001163280.1	Gene:	TBPH / 37781	FlyBaseID:	FBgn0025790	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001254189.1	Gene:	tdp-1 / 174436	WormBaseID:	WBGene00006514	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	372	Identity:	122/372 - (32%)
Similarity:	183/372 - (49%)	Gaps:	78/372 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DFVQVSEEEGDEPIELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRSNEG--RLFPPS 64
            :|:.|.:..||||||||. .||.:|::||||.|||:.||||:|..|.|.|.|:.:..  :|..|:
Worm    46 EFITVQDPNGDEPIELPT-VDGVVLMTTLQASFPGATGLKYKNPKTGANRAVQVDPSGLKLIAPA 109

  Fly    65 VESGWGEYAYFCVFPKENKR-----------------------KSDDNLENSTAKTKRIETRLRC 106
              .||....:|.:...:::|                       .|||..:..:.:.:.:|...:.
Worm   110 --DGWENKTFFVIVAPQSERVRALSSADATSAKRRKVGSSDDSDSDDGRDGRSGRKRAVERDSQP 172

  Fly   107 TDLIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLT-NRHL 170
            .||||||:.:|||:|..::|||..|.|:..:||:.: .|.||||||||..|...|.:||. .:|:
Worm   173 VDLIVLGVDFKTTDECFQKYFEDIGTVVFCEIKRKS-DGNSKGFGFVRMSSVGEQNKVLAIPQHM 236

  Fly   171 IDGRWCEVKVPNSKGM----GHQVPCKVFVGRCTEDINSDDLREYFS-------KFGEVTDVFIP 224
            ||||.|:||||:.:.:    |.....::||||.|:.::...||:.|.       :...|||||||
Worm   237 IDGRRCDVKVPDGRSLQDKQGRPSISRIFVGRLTDKVDEHQLRKVFGDEAKSYIETAVVTDVFIP 301

  Fly   225 RPFRAFSFVTFLDPDVAQSLCGEDHI-IKGVSVHVSNAAPKAEQN-------------RNQQ--- 272
            :|||.|:|||....:.|:.:..:..: :.|:||.:|.|.|:.|.|             ||::
Worm   302 KPFRGFAFVTLSSAEAAERIVSKGSLTVNGLSVGLSIAQPREENNQSVGPDYGLPAGYRNRRERD 366

  Fly   273 --------------------VQSYNYNSANSFGMHSYHPQGNHMNPG 299
                                .|.|:|...||.....|...|:...||
Worm   367 RPDRRPIQNEAPLPMPFVRPPQDYSYRQQNSPLERRYWAPGDSRGPG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_001163280.1	RRM1_TDP43	108..184	CDD:240767	40/76 (53%)
TBPH	NP_001163280.1	RRM2_TDP43	192..261	CDD:240768	27/76 (36%)
tdp-1	NP_001254189.1	RRM_SF	174..247	CDD:302621	38/73 (52%)
tdp-1	NP_001254189.1	RRM_SF	262..339	CDD:302621	27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167672
Domainoid	1	1.000	64	1.000	Domainoid score	I6685
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134087
Inparanoid	1	1.050	183	1.000	Inparanoid score	I2627
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1425837at2759
OrthoFinder	1	1.000	-	-		FOG0005498
OrthoInspector	1	1.000	-	-		otm14766
orthoMCL	1	0.900	-	-		OOG6_105367
Panther	1	1.100	-	-	LDO	PTHR48033
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3811
SonicParanoid	1	1.000	-	-		X3916
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.930