Protein Alignment TBPH and tiar-1

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_495121.1
• Gene: tiar-1 / 173967
• WormBaseID: WBGene00015943
• Length: 408
• Species: Caenorhabditis elegans
• Alignment Length: 456
• Identity: 109/456 - (23%)
• Similarity: 174/456 - (38%)
• Gaps: 118/456 - (25%)

  Fly     5 QVSEEEG-------DEP-------IELPAEEDGTLLLSTLQAQFPGSCGLKYRNLDTKAVRGVRS 55
            :::|.||       |||       ::....||   .::||..|. ||.      ..||.:.. .|
 Worm    29 KLAEREGFHLGNGSDEPRTLYVGNLDSTVTED---FIATLFNQI-GSV------TKTKVIFD-GS 82

  Fly    56 NEGRLFPPSVESGWGEYAYFCVFPKENKR-------KSDDNLENSTAKTKRIETRLRCTDLIVLG 113
            |:...|....:.|....|    ....|||       |.:..:|....::| |:| .|...:.|..
 Worm    83 NDPYAFVEFSDHGQASQA----LQTMNKRLLLDREMKVNWAVEPGQQQSK-IDT-TRHFHVFVGD 141

  Fly   114 LPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVL-------TNRHLI 171
            |..:...:.|||.|:.:|:|..|::.:||.:.:|||:|||.:...:...|.:       ..|..|
 Worm   142 LSSEVDNQKLREAFQPFGDVSDAKVIRDTNTTKSKGYGFVSYPKREEAERAIEQMNGQWLGRRTI 206

  Fly   172 DGRWCEVKVPNSKGMGHQVP--------------CKVFVGRCTEDINSDDLREYFSKFGEVTDVF 222
            ...|...|..:.:...|...              ..|:||... .:..|::|:.|:.||.:|:|.
 Worm   207 RTNWATRKPGDQEKPSHYNEKSYDEIYNQTSGDNTSVYVGNIA-SLTEDEIRQGFASFGRITEVR 270

  Fly   223 IPRPFRAFSFVTFLDPDVAQSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMH 287
            |.: .:.::||.|.:.|.|         .|.: |.::|      |:...|:...::......|.
 Worm   271 IFK-MQGYAFVKFDNKDAA---------AKAI-VQMNN------QDVGGQLVRCSWGKTGDTGK- 317

  Fly   288 SYHPQGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYHNNGGN 352
              .|.|::      |:..||   ::.||.:.        ..:||| ||..|||..|||.|...|.
 Worm   318 --TPGGSY------GYGYGN---SSSGGNSQ--------PYSGYG-GGGAYGGGQGGGGHGGPGQ 362

  Fly   353 HSSGGNTNRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSN 417
            ..|..|:......:||   .:|...|.|       .||.|..:|          |...|.:|..:
 Worm   363 QQSNANSQYWQYYAQY---YNNPQLMQQ-------WSNYWQQQG----------GAPQQQNSGGH 407

  Fly   418 Q 418
            |
 Worm   408 Q 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833	20/86 (23%)
		RRM1_TDP43	108..181	CDD:409760	22/79 (28%)
		RRM2_TDP43	192..261	CDD:409761	18/68 (26%)
tiar-1	NP_495121.1	PABP-1234	47..>302	CDD:130689	66/289 (23%)
		RRM2_TIA1_like	136..210	CDD:409789	20/73 (27%)