DRSC/TRiP Functional Genomics Resources

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Protein Alignment TBPH and MSI2

DIOPT Version :10

Sequence 1:NP_477400.1 Gene:TBPH / 37781 FlyBaseID:FBgn0025790 Length:531 Species:Drosophila melanogaster
Sequence 2:XP_005257072.1 Gene:MSI2 / 124540 HGNCID:18585 Length:346 Species:Homo sapiens


Alignment Length:396 Identity:94/396 - (23%)
Similarity:148/396 - (37%) Gaps:92/396 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSYDAQMRVLTN-RHLID 172
            :.:.||.|:|:.:|||:||..:||:....:.:|..:.:|:|||||.|....:..:||.. .|.:|
Human    23 MFIGGLSWQTSPDSLRDYFSKFGEIRECMVMRDPTTKRSRGFGFVTFADPASVDKVLGQPHHELD 87

  Fly   173 GRWCEVKVPNSKGMGHQVPC---KVFVGRCTEDINSDDLREYFSKFGEVTDVFI-----PRPFRA 229
            .:..:.||...:....::..   |:|||..:.:...:|:::||.:||:|.|..:     ....|.
Human    88 SKTIDPKVAFPRRAQPKMVTRTKKIFVGGLSANTVVEDVKQYFEQFGKVEDAMLMFDKTTNRHRG 152

  Fly   230 FSFVTFLDPDVAQSLCG-EDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHPQG 293
            |.||||.:.||.:.:|. ..|.|....|....|.||...                          
Human   153 FGFVTFENEDVVEKVCEIHFHEINNKMVECKKAQPKEVM-------------------------- 191

  Fly   294 NHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGM-GGNNYGGNSGGGYHNNGGNHSSGG 357
              ..||..|..||             :|...:....|.|| |..|:....|.||.....::    
Human   192 --FPPGTRGRARG-------------LPYTMDAFMLGMGMLGYPNFVATYGRGYPGFAPSY---- 237

  Fly   358 NTNRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGHLDMPNLQALGINSQGSSSSNQGQNM 422
                   |.|:....:..:|  ......|..:.|.:...:...||.        |:.:|..|.| 
Human   238 -------GYQFPGFPAAAYG--PVAAAAVAAARGSVLNSYSAQPNF--------GAPASPAGSN- 284

  Fly   423 SNQSMLNLNSLPINPALVAAALNQWSLVGNQLQNQNQDQQGGNFLSWMA-QNG---GHNNANNFG 483
                       |..|.....| |....|.:.....:||...||::|..: |.|   ||..|:..|
Human   285 -----------PARPGGFPGA-NSPGPVADLYGPASQDSGVGNYISAASPQPGSGFGHGIASIPG 337

  Fly   484 --GRKG 487
              |:.|
Human   338 CPGKTG 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TBPHNP_477400.1 TDP43_N 3..78 CDD:465833
RRM1_TDP43 108..181 CDD:409760 24/72 (33%)
RRM2_TDP43 192..261 CDD:409761 23/77 (30%)
MSI2XP_005257072.1 RRM1_MSI2 17..109 CDD:410153 25/85 (29%)
RRM2_MSI 111..184 CDD:240769 23/72 (32%)
Blue background indicates that the domain is not in the aligned region.

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