Protein Alignment TBPH and HNRNPA0

DIOPT Version :10

• Sequence 1: NP_477400.1
• Gene: TBPH / 37781
• FlyBaseID: FBgn0025790
• Length: 531
• Species: Drosophila melanogaster
• Sequence 2: NP_006796.1
• Gene: HNRNPA0 / 10949
• HGNCID: 5030
• Length: 305
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 88/306 - (28%)
• Similarity: 134/306 - (43%)
• Gaps: 45/306 - (14%)

  Fly   109 LIVLGLPWKTTEESLREYFETYGEVLMAQIKKDTKSGQSKGFGFVRFGSY-DAQMRVLTNRHLID 172
            |.:.||..:|:|..||.:||.:|.:....:..:.::.:|:.||||.:.:. :|...:..:.|.:|
Human     9 LFIGGLNVQTSESGLRGHFEAFGTLTDCVVVVNPQTKRSRCFGFVTYSNVEEADAAMAASPHAVD 73

  Fly   173 GRWCEVK-----VPNSKGMGHQVPCKVFVGRCTEDINSDDLREYFSKFG--EVTDVFIPRPF--- 227
            |...|:|     ..:::...|....|:|||....|:...||.|:||:||  |..::...:..
Human    74 GNTVELKRAVSREDSARPGAHAKVKKLFVGGLKGDVAEGDLIEHFSQFGTVEKAEIIADKQSGKK 138

  Fly   228 RAFSFVTFLDPDVA-QSLCGEDHIIKGVSVHVSNAAPKAEQNRNQQVQSYNYNSANSFGMHSYHP 291
            |.|.||.|.:.|.| ::...:.|.|:|..|.|..|.||.:          .|:.....|..|  .
Human   139 RGFGFVYFQNHDAADKAAVVKFHPIQGHRVEVKKAVPKED----------IYSGGGGGGSRS--S 191

  Fly   292 QGNHMNPGRNGHHRGNNQHNAHGGENAIVPNNHNIGTAGYGMGGNNYGGNSGGGYH---NNGGNH 353
            :|.....||.|   |.:|:....|           |..||...| .|||..||||:   ..||..
Human   192 RGGRGGRGRGG---GRDQNGLSKG-----------GGGGYNSYG-GYGGGGGGGYNAYGGGGGGS 241

  Fly   354 SSGGNT--NRQDGGSQYNSRQSNFHGMNQPHNGNVGGSNGWMNRGH 397
            |.||:.  |...|...|:..||::..|.....|..|||: |..|.:
Human   242 SYGGSDYGNGFGGFGSYSQHQSSYGPMKSGGGGGGGGSS-WGGRSN 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TBPH	NP_477400.1	TDP43_N	3..78	CDD:465833
		RRM1_TDP43	108..181	CDD:409760	21/77 (27%)
		RRM2_TDP43	192..261	CDD:409761	25/74 (34%)
HNRNPA0	NP_006796.1	RRM1_hnRNPA0	5..83	CDD:409764	21/73 (29%)
		RRM2_hnRNPA0	99..178	CDD:409993	28/78 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..214		12/65 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..305		9/26 (35%)