Protein Alignment Pym and PYM1

DIOPT Version :9

• Sequence 1: NP_726372.1
• Gene: Pym / 37780
• FlyBaseID: FBgn0034918
• Length: 207
• Species: Drosophila melanogaster
• Sequence 2: NP_115721.1
• Gene: PYM1 / 84305
• HGNCID: 30258
• Length: 204
• Species: Homo sapiens
• Alignment Length: 215
• Identity: 72/215 - (33%)
• Similarity: 118/215 - (54%)
• Gaps: 48/215 - (22%)

  Fly    10 GKFIPATKRPDGTWRKARRVKDGYVPQEEVPLYESKGKQFVAQRQAGVPPGMCPLLAAESKKERE 74
            ||:|.:|:||||||||.||||:|||||||||:||:|..:|...:.. :|||:.|...|.....|
Human    13 GKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPE-LPPGLSPEATAPVTPSR- 75

  Fly    75 KQERTRAKKQEKESGRQPKAPAPGVLVMPPSTCPPPKVSQQQQQQQQQPSG-----SRDINSISK 134
                             |:...||:     |......:.::::::|||..|     ||.::.:|
Human    76 -----------------PEGGEPGL-----SKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVS- 117

  Fly   135 TLEDTLKLDAAQE-----------------VVDPAKQLKKLRKKIREIEQIESRIQAGEQKKLDK 182
             ||:|.:|.:|.:                 ..:.||::|.|:||:|::|:::.||||||..:..|
Human   118 -LEETAQLPSAPQGSRAAPTAASDQPDSAATTEKAKKIKNLKKKLRQVEELQQRIQAGEVSQPSK 181

  Fly   183 DQLDKVKKKSEILRQIKDLE 202
            :||:|:.::..:..:::|||
Human   182 EQLEKLARRRALEEELEDLE 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pym	NP_726372.1	Mago-bind	11..35	CDD:286378	17/23 (74%)
PYM1	NP_115721.1	Required for interaction with MAGOH and RBM8A	1..33		14/19 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		13/18 (72%)
		Mago-bind	14..38	CDD:312698	17/23 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	55..151		22/121 (18%)
		eIF2A-like	152..204		20/50 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11946
eggNOG	1	0.900	-	-		E1_KOG4325
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I4773
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59719
OrthoDB	1	1.010	-	-		D1545729at2759
OrthoFinder	1	1.000	-	-		FOG0004103
OrthoInspector	1	1.000	-	-		oto90397
orthoMCL	1	0.900	-	-		OOG6_105546
Panther	1	1.100	-	-	LDO	PTHR22959
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3921
SonicParanoid	1	1.000	-	-		X3373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870