Protein Alignment KCNMA1 and SLO2

DIOPT Version :10

• Sequence 1: XP_016871696.1
• Gene: KCNMA1 / 3778
• HGNCID: 6284
• Length: 1311
• Species: Homo sapiens
• Sequence 2: NP_001097259.2
• Gene: SLO2 / 5740325
• FlyBaseID: FBgn0261698
• Length: 1878
• Species: Drosophila melanogaster
• Alignment Length: 1454
• Identity: 279/1454 - (19%)
• Similarity: 458/1454 - (31%)
• Gaps: 533/1454 - (36%)

Human   275 LRFIAANDKLW-------FWLEVNSVVDF-FTV--PP---VFVSVYLNRSWLGLRFL-------- 318
            |.::.....:|       |.||:.:.:.| .|:  ||   :|:.::|| .||..|.|
  Fly   214 LTYLGYKGNIWQQILSFHFILELVTTIPFALTIVHPPLRNLFIPIFLN-CWLAKRSLENMFNDLH 277

Human   319 RALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQ--NNQAL 381
            ||::..| |.:.|.|.||                     :|..:.||..|....::||  .::.|
  Fly   278 RAMQKSQ-SALSQQLTIL---------------------SATLLCLVFTSVCGIQHFQRAGHRHL 320

Human   382 TYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYS 446
            ..::..|.::||.|||||||........:|:||..|...|.:..:...::......|:|.|||||
  Fly   321 NLFQSTYYVVVTFSTVGYGDFVPDIWPSQLYMVIMICVALIVLPTQFEQLAFTWMERQKLGGSYS 385

Human   447 A--VSGRKHIVVCGHITL--ESVSNFLKDF-LHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQ 506
            :  ....||:|||. .||  :::.:||.:| .|....|..|.:     :|| :||:... |...|
  Fly   386 SHRAQSEKHVVVCS-TTLHADTIMDFLNEFYAHPLLQDFYVVL-----LSP-MELDTTM-RMILQ 442

Human   507 VE-------FYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIR 564
            |.       :.|||.|...||||.::..|:||.|||.:..||..|.|...|:|..::|::.|.:.
  Fly   443 VPIWAQRVIYIQGSCLKDGDLARARMNEAEACFILAARNYADKTAADEHTILRSWAVKDFAPNVP 507

Human   565 IITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLF--SMRSFIK 627
            ...|:.:..:|.|:        |..:..:|..|.|...:|.:|...|.||::..|.  |.....:
  Fly   508 QYVQIFRPEHKLHV--------KFAEHVVCEDEFKYALLANNCTCPGASTLVTLLLHTSRGQEGQ 564

Human   628 IEEDTWQKYYLEGVSNEMY----------TEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSA 682
            ...:.|.:.|.:...||:|          .||...:|...||.:     ..|..:.::.:  :.|
  Fly   565 QSPEEWHRLYGKCSGNEIYHIVLGDSRFFGEYEGKSFTYASFHS-----HRKYGVALVGV--RPA 622

Human   683 NRESRSRKRILINPG-NHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCG---- 742
            .......:.||:||| .|:..::.|.  :..|..||...||.   ...:..:||....|.|
  Fly   623 ELPEFYEETILLNPGPRHIMKKDDTC--YYMSITKEENSAFV---VNQNQTSDPTAAAKEGSGTG 682

Human   743 --------------------------------------------------------------CKR 745
                                                                          ...
  Fly   683 GGGGASSSASHHHTAATANPTTTITTTVQATTTTISTTFTSSTLLSASTTTATINATSTAAAAPP 747

Human   746 PKMSIYKRMRRACCFDCG--------------------------------------RSERDCSCM 772
            |..|:..|:..:..:|.|                                      .||...:.:
  Fly   748 PVPSVCVRVPHSPSYDSGGGTTGTTHLQPYPYPQSYPQPHPPMQTPDSGEFASLFVPSENPTAVI 812

Human   773 SGRVRGNV-DT---------------------------------------LERAFPL-SSVSV-- 794
            ....|.|: ||                                       |..|..: :|:|:
  Fly   813 ISDSRQNLKDTTVTQTAATITTTTLPPPPQTMGSPSMAGGSGGCGGGGLGLGSAHSMGTSLSITP 877

Human   795 -------NDCSTSFRAFEDEQPSTLSPK-KKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMD 851
                   |.....|.    ..|:.|||. ..||.|..|.|....|.:.......|.|||..:..|
  Fly   878 ATLTTTGNHLDVPFA----NNPNLLSPDVLNQRRGSRRPSILPVPDMFTSSSFSIAGNDDGEEGD 938

Human   852 SNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGH--------VVV----------CIF--- 895
            .:..:.|..  ..|.:|.|           .:..|.||        :::          |.|
  Fly   939 ESDDEIDDE--MPWRSPSE-----------KIACLGGHFPQSRTYSLIMSSSEDSYQRGCSFCSA 990

Human   896 -GDVSSALIGLRNLVMPLRA-----------------------SNFHYHELKHIVFVGSIEYLKR 936
             ...|:|.:.:.....|..|                       |..:..:|:..|       :|:
  Fly   991 TASASAAAVAVAVAAAPAPAPAPAYPSDSAGESGTNADSAAMPSEEYLPQLRRRV-------MKK 1048

Human   937 EW---ETLHNFPKVSI-------LPGTPLSRADLRAVNINLCDMC----------------VILS 975
            .:   ....:.|.:.:       |.|..|:|...|...:..|..|                ..::
  Fly  1049 SYSCDSECRSVPGMGMGMAMGVGLGGGTLARLAARRRQLQRCSSCSCSTATTTTTPAVAATTAMA 1113

Human   976 ANQNNIDDTS--------------LQDKECILASL------------------------------ 996
            |.......||              :.|..||:...
  Fly  1114 AGSGATAFTSSSSVETRRPVRPVWVYDYSCIVKGFPPVSPFIGVSPTLCYLLKEKKPLCCLQLAQ 1178

Human   997 --------NIKSMQFDDSIGVLQAN--SQG---FTPP--GMDRSSPDNSPVHGML-RQPSIT--- 1042
                    |.|..|:.:...:|.|:  |.|   |..|  ...||....:|:..:| |:|.:.
  Fly  1179 VCEHCSYRNAKEYQWQNKTIILAADYASNGIYNFIIPLRAHFRSKTSLNPIILLLERRPDVAFLD 1243

Human  1043 -----------TGVNIPIITELAKPG---KLPLVSVNQEKNSGTH-------------------- 1073
                       .| :|..:.:|.:.|   ...:|.||:|.::...
  Fly  1244 ALSYFPLVYWMLG-SIDCLDDLLRAGITLAESVVVVNKELSNSAEEDSLSDCNTIVAVQNMFKFF 1307

Human  1074 --ILMITELVNDTNVQFLDQDDDDDPDTELYLTQ------------------PFACGTAFAVSVL 1118
              |..||||...:|::|:.....|  ...|:|::                  |||.|..|:.|:|
  Fly  1308 PSIKSITELSQSSNMRFMQFRAHD--KYALHLSKMEKREKERGSHISYMFRLPFAAGAVFSASML 1370

Human  1119 DSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR-CRVAQLALLD 1182
            |:|:...:..|.::|.:|            .|:..:.|...|:.|...:...|. .|.
  Fly  1371 DTLLYQAFVKDYVITFVR------------LLLGIDQAPGSGFLTSMRITKDDMWIRT------- 1416

Human  1183 GPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYE----FELVP 1243
                       ||.|:.|...|...:..||||.:|...:..|.      ::|.|.|    |....
  Fly  1417 -----------YGRLYQKLCSTTCEIPIGIYRTQDTSNADTSH------VSNSPVERWGPFSAFS 1464

Human  1244 TDLIFCLMQFDHNAG-----------------QSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQ 1291
            ...:.....:|...|                 :...|.:..:.|.:...::..||:.:...:.|:
  Fly  1465 RHCVRLRPSYDEETGTPDSTKDSTEMLRGVTYRPPGSATGGASSFRPQPQRQRSVNCLGGCSERK 1529

Human  1292 NRPKS----RESRDKQNRKEMVYR 1311
            ....|    .|:||  |..:.:.|
  Fly  1530 GSSYSINLADEARD--NHAQQIER 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNMA1	XP_016871696.1	Ion_trans	223..440	CDD:459842	47/187 (25%)
		TrkA	387..>567	CDD:440335	64/191 (34%)
		BK_channel_a	590..677	CDD:460947	21/98 (21%)
SLO2	NP_001097259.2	Ion_trans_2	<319..363	CDD:462301	16/43 (37%)
		BK_channel_a	525..619	CDD:460947	21/98 (21%)